Increased fibronectin expression in lung in the setting of chronic alcohol abuse.

Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Research Abstract Details 

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Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Abstract Text:

Ellen L Burnham,Marc Moss,Jeffrey D Ritzenthaler,Jesse Roman,

RATIONALE: The incidence and severity of the acute respiratory distress syndrome (ARDS) is increased in individuals who abuse alcohol. One possible mechanism by which alcohol increases susceptibility to acute lung injury is through alterations in alveolar macrophage function and induction of tissue remodeling activity. Our objective was to determine whether alcohol abuse, independent of other comorbidities, alters fibronectin and metalloproteinase gene expression in alveolar macrophages and in epithelial lining fluid (ELF) of the lung. METHODS: Otherwise healthy subjects with alcohol abuse (n=21) and smoking-matched controls (n=17) underwent bronchoalveolar lavage. Alveolar macrophage fibronectin and matrix metalloproteinase (MMP) mRNA expression were measured via reverse transcription-polymerase chain reaction. The supernatant from cultured alveolar macrophages and lung ELF were tested for their ability to induce fibronectin and MMP-9 gene transcription in cell-based assays. RESULTS: Alveolar macrophages from subjects with alcohol abuse demonstrated increased fibronectin mRNA expression (p<0.001), and their ELF also elicited more fibronectin gene transcription in lung fibroblasts compared with controls (p<0.001). In contrast, alveolar macrophages from subjects with alcohol abuse had decreased MMP-9 and MMP-2 mRNA expression (p<0.03 and p<0.005, respectively). Similarly, the supernatant (p<0.001) and ELF (p<0.01) from these subjects induced less MMP-9 gene transcription in THP-1 cells. DISCUSSION: Alcohol abuse is associated with increased fibronectin mRNA expression in alveolar macrophages and increased fibronectin-inducing activity in the ELF. This appears to be a specific effect as other tissue remodeling genes, such as MMPs, were not equally affected. These findings suggest activation of tissue remodeling that may contribute to the increased susceptibility for the ARDS observed in alcoholism.

Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Publishing Authors By Initials

EL Burnham,M Moss,JD Ritzenthaler,J Roman,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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MEDLINE DATE:

Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Alcoholism, clinical and experimental research

VOLUME: 31

Page Numbers: 675-83

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 3

MONTH: Apr

YEAR: 2007

Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707242

Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Information

Substance Name: Matrix Metalloproteinases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Increased fibronectin expression in lung in the setting of chronic alcohol abuse.

AFFILIATION: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Ellen.Burnham@uchsc.edu

Country: England

AGENCY: United States NIAAA

GRANT: P50AA013757

ACRONYM: AA

MEDLINETA: Alcohol Clin Exp Res

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