Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma.

Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. Research Abstract Details 

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Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. Abstract Text:

Samantha W M Lun,C K Wong,Fanny W S Ko,David S C Hui,Christopher W K Lam,Samantha W M Lun,C K Wong,Fanny W S Ko,David S C Hui,Christopher W K Lam,

CD26, which is a costimulatory molecule and peptidase, is responsible for the degradation of interferon (IFN)-gamma-induced chemokines. To elucidate the immunopathological role of CD26 in allergic asthma, we investigated plasma soluble CD26 (sCD26) concentration and its cell surface expression on lymphocytes, monocytes, CD4+ T helper, CD8+ T suppressor plus cytotoxic T, invariant natural killer T (iNKT), and CD19+ B lymphocytes in allergic asthmatic patients. Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface expression of CD26 was significantly up-regulated on lymphocytes, especially on CD4+ and iNKT lymphocytes (all P < 0.05), but not on other cell types. Significant positive correlations were found between sCD26 and the percentage of eosinophils, Th2-related chemokines CCL5 and CCL22, and costimulatory molecule sCTLA-4 (all P < 0.05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in the immunopathogenesis of allergic asthma.

Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. Publishing Authors By Initials

SW Lun,CK Wong,FW Ko,DS Hui,CW Lam,SW Lun,CK Wong,FW Ko,DS Hui,CW Lam,

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Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical immunology

VOLUME: 27

Page Numbers: 430-7

Journal Abbreviation: J. Clin. Immunol.

ISSN: 0271-9142

DAY: 25

MONTH: 05

YEAR: 2007

Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Country: United States

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MEDLINETA: J Clin Immunol

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