Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis.

Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Research Abstract Details 

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Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Abstract Text:

Edward P Moran,Devendra K Agrawal,

Vascular remodeling and atheromatous lesion formation are determined in part by the balance between apoptosis and survival of vascular smooth muscle cells (VSMCs). In the chronic stages, apoptosis of VSMCs in the atherosclerotic plaques contributes to the weakening and potential rupture of the plaque causing pathologies such as acute coronary syndrome. The higher incidence of apoptosis in the plaques of symptomatic than in asymptomatic patients has been demonstrated, but the expression of survival proteins, including the inhibitor of apoptosis proteins (IAPs), has not been thoroughly examined. The aim of this study was to investigate the immunohistochemical expression of cellular inhibitor of apoptosis protein-2 (cIAP2), x-linked inhibitor of apoptosis protein (XIAP), and survivin in normal carotid arteries, and carotid endarterectomy specimens of symptomatic and asymptomatic patients with carotid stenosis. The results demonstrated stronger immunopositivity to smooth muscle myosin heavy chain antigen (SM-MHC) (sm2), proliferating cell nuclear antigen (PCNA), and p50 subunit of NF-kappabeta in the asymptomatic plaques than in symptomatic plaques. Furthermore, there was higher expression of cIAP2, XIAP, and survivin in the symptomatic than in the asymptomatic plaques and this paralleled caspase-3 expression. The increased expression of IAPs in symptomatic plaques could be due to endogenous defense mechanism to protect against the pro-apoptotic effect of the inflammatory stimuli that are released in the plaques. This could be involved in the stabilization of symptomatic atheromatous plaques and may prove a potential therapeutic target.

Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Publishing Authors By Initials

EP Moran,DK Agrawal,

For similar cells: muscle cells: myocytes, smooth muscle research abstracts see: cells: muscle cells: myocytes, smooth muscle research

PUBMED ID PMID:

MEDLINE DATE:

Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental and molecular pathology

VOLUME: 83

Page Numbers: 11-6

Journal Abbreviation: Exp. Mol. Pathol.

ISSN: 0014-4800

DAY: 17

MONTH: 01

YEAR: 2007

Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370711

Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Keywords Mesh Terms:

KEYWORDS: Myocytes, Smooth Muscle

MESH TERMS: metabolism

Chemical & Substance for Abstract: Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Information

Substance Name: Inhibitor of Apoptosis Proteins

Registry Number: 0

Grant and Affiliation Information for Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis.

AFFILIATION: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01HL07349

ACRONYM: HL

MEDLINETA: Exp Mol Pathol

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