Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors.

Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors. Research Abstract Details 

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Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors. Abstract Text:

Yukinari Kato,Norihito Hayatsu,Mika Kato Kaneko,Satoshi Ogasawara,Tetsutaro Hamano,Satoru Takahashi,Ryo Nishikawa,Masao Matsutani,Kazuhiko Mishima,Hisashi Narimatsu,Yukinari Kato,Norihito Hayatsu,Mika Kato Kaneko,Satoshi Ogasawara,Tetsutaro Hamano,Satoru Takahashi,Ryo Nishikawa,Masao Matsutani,Kazuhiko Mishima,Hisashi Narimatsu,

Keratan sulfate (KS) proteoglycans are expressed on a subpopulation of microglia in normal adult brain. We previously showed the up-regulated expression of KS in one of glioblastoma cell lines using anti-KS antibody (5D4). However, it has not been clarified whether KS is expressed in brain tumors and is involved in their malignancy. In this study, 54 astrocytic tumors were investigated about KS-expression using Western-blot with 5D4. In six of 14 anaplastic astrocytomas (43%) and 23 of 34 glioblastomas (68%), KS was detected by 5D4. KS was hardly detected by 5D4 in diffuse astrocytoma, suggesting that KS-expression is significantly expressed in malignant astrocytic tumors. In immunohistochemistry, KS is highly expressed in cell surface of malignant astrocytic tumors. Taken together, KS might be associated with the malignancy of astrocytic tumors, and be useful for a prognostic factor of astrocytic tumors.

Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors. Publishing Authors By Initials

Y Kato,N Hayatsu,MK Kaneko,S Ogasawara,T Hamano,S Takahashi,R Nishikawa,M Matsutani,K Mishima,H Narimatsu,Y Kato,N Hayatsu,MK Kaneko,S Ogasawara,T Hamano,S Takahashi,R Nishikawa,M Matsutani,K Mishima,H Narimatsu,

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Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 369

Page Numbers: 1041-6

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ISSN: 1090-2104

DAY: 7

MONTH: 03

YEAR: 2008

Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors. Information

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LANGUAGE: eng

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AFFILIATION: Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Open Space Laboratory C-2, 1-1-1, Tsukuba, Ibaraki 305-8568, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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