Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin.

Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Research Abstract Details 

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Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Abstract Text:

Nobuyuki Takahashi,Feng Li,Kunjie Hua,Jianbei Deng,Chih-Hong Wang,Robert R Bowers,Timothy J Bartness,Hyung-Suk Kim,Joyce B Harp,Nobuyuki Takahashi,Feng Li,Kunjie Hua,Jianbei Deng,Chih-Hong Wang,Robert R Bowers,Timothy J Bartness,Hyung-Suk Kim,Joyce B Harp,

An overactive renin-angiotensin system is associated with obesity and the metabolic syndrome. However, the mechanisms behind it are unclear. Cleaving angiotensinogen to angiotensin I by renin is a rate-limiting step of angiotensin II production, but renin is suggested to have angiotensin-independent effects. We generated mice lacking renin (Ren1c) using embryonic stem cells from C57BL/6 mice, a strain prone to diet-induced obesity. Ren1c(-/-) mice are lean, insulin sensitive, and resistant to diet-induced obesity without changes in food intake and physical activity. The lean phenotype is likely due to a higher metabolic rate and gastrointestinal loss of dietary fat. Most of the metabolic changes in Ren1c(-/-) mice were reversed by angiotensin II administration. These results support a role for angiotensin II in the pathogenesis of diet-induced obesity and insulin resistance.

Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Publishing Authors By Initials

N Takahashi,F Li,K Hua,J Deng,CH Wang,RR Bowers,TJ Bartness,HS Kim,JB Harp,N Takahashi,F Li,K Hua,J Deng,CH Wang,RR Bowers,TJ Bartness,HS Kim,JB Harp,

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Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell metabolism

VOLUME: 6

Page Numbers: 506-12

Journal Abbreviation: Cell Metab.

ISSN: 1550-4131

DAY: 6

MONTH: Dec

YEAR: 2007

Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Information

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LANGUAGE: eng

NlmUniqueID: 101233170

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Grant and Affiliation Information for Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin.

AFFILIATION: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ntakaha@med.unc.edu

Country: United States

AGENCY: United States NIDDK

GRANT: P30DK56350

ACRONYM: DK

MEDLINETA: Cell Metab

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