Increased concordance of severe respiratory syncytial virus infection in identical twins.

Increased concordance of severe respiratory syncytial virus infection in identical twins. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increased concordance of severe respiratory syncytial virus infection in identical twins. Abstract Text:

OBJECTIVE. We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS. Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS. Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS. The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

Increased concordance of severe respiratory syncytial virus infection in identical twins. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Increased concordance of severe respiratory syncytial virus infection in identical twins. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatrics

VOLUME: 121

Page Numbers: 493-6

Journal Abbreviation: Pediatrics

ISSN: 1098-4275

DAY: 3

MONTH: Mar

YEAR: 2008

Increased concordance of severe respiratory syncytial virus infection in identical twins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376422

Increased concordance of severe respiratory syncytial virus infection in identical twins. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Increased concordance of severe respiratory syncytial virus infection in identical twins. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Increased concordance of severe respiratory syncytial virus infection in identical twins.

AFFILIATION: Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 60 DK-2400 Copenhagen NV, Denmark. sft@city.dk.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatrics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increased concordance of severe respiratory syncytial virus infection in identical twins Related Publications

• A study of risk factors associated with Newcastle disease epidemics in village free-range chickens in Uganda.
• Actinobacillus muris sp. nov. isolated from mice.
• Age dependent systemic exposure to inhaled salbutamol.
• Ambient air pollution triggers wheezing symptoms in infants.
• Arthritis in ducks I. aetiology and public health aspects.
• Assessment of bronchial hyperresponsiveness in preschool children: methodological issues.
• Avian pasteurellosis: Taxonomy of the organisms involved and aspects of pathogenesis.
• Characterization of Salmonella enterica serovar gallinarum biovars gallinarum and pullorum by plasmid profiling and biochemical analysis.
• Characterization of small-colony variants of Enterococcus faecalis isolated from chickens with amyloid arthropathy.
• Comparative investigations of Pasteurella haemolytica sensu stricto and so-called P. haemolytica isolated from different pathological lesions in pigs.
• Correlation between viable counts of Salmonella Gallinarum in spleen and liver and the development of anaemia in chickens as seen in experimental fowl typhoid.
• Demands on spacer devices for young children.
• Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children.
• Feasibility of repetitive lung function measurements by raised volume rapid thoracoabdominal compression during methacholine challenge in young infants.
• Genomic relationships between selected phage types of Salmonella enterica subsp. enterica serotype typhimurium defined by ribotyping, IS200 typing and PFGE.
• Hatchery-borne Salmonella enterica serovar Tennessee infections in broilers.
• Impact of coccidial infection on vaccine- and vvIBDV in lymphoid tissues of SPF chickens as detected by RT-PCR.
• Increased concordance of severe respiratory syncytial virus infection in identical twins.
• Isolation and characterization of some previously unreported taxa from poultry with phenotypical characters related to Actinobacillus-an Pasteurella species.
• Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.
• Persistence of Salmonella Senftenberg in poultry production environments and investigation of its resistance to desiccation.
• Phenotypic and genotypic characters of isolates of Pasteurella multocida obtained from back-yard poultry and from two outbreaks of avian cholera in avifauna in Denmark.
• Plasmid profiles and phage types of Salmonella typhimurium isolated from successive flocks of chickens on three parent stock farms.
• Ribotypes of Salmonella enterica serovar Gallinarum biovars gallinarum and pullorum.
• Salmonella enterica serovar Gallinarum biovar gallinarum in layers: Epidemiological investigations of a recent outbreak in Denmark.
• Salpingitis in web-footed birds: Prevalence, aetiology and significance.
• Sensitization does not develop in utero.
• Towards improved aerosol devices for the young child.
• Ultraviolet detectors in thin sputtered ZnO films.
• Use of inhaled corticosteroids in pediatric asthma.