Increased bioavailability of a transdermal application of a nano-sized emulsion preparation.

Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. Research Abstract Details 

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Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. Abstract Text:

T Kotyla,F Kuo,V Moolchandani,T Wilson,R Nicolosi,T Kotyla,F Kuo,V Moolchandani,T Wilson,R Nicolosi,

The aim of this study was to compare the transdermal application of a nano-sized emulsion versus a micron-sized emulsion preparation of delta tocopherol as it relates to particle size and bioavailability. Two separate experiments were performed using seven F1B Syrian Golden hamsters, 1 week apart. Each emulsion preparation consisted of canola oil, polysorbate 80, deionized water and delta tocopherol; the only difference between the two preparations was processing the nano-sized emulsion with the Microfluidizer Processor. Both were formulated into a cream and applied to the shaven dorsal area. The particle size of the micron-sized emulsion preparation was 2788 nm compared to 65 nm for the nano-sized emulsion formulation. Two hours post-application, hamsters that were applied the nano-sized emulsion had a 36-fold significant increase of plasma delta tocopherol, where as hamsters that were applied the micron-sized emulsion only had a 9-fold significant increase, compared to baseline, respectively. At 3h post-application, plasma delta tocopherol had significantly increased 68-fold for hamsters applied the nano-sized emulsion, whereas only an 11-fold significant increase was observed in hamsters applied the micron-sized emulsion, compared to baseline, respectively. Significant differences were also observed between the nano-sized and micron-sized emulsion at 2 and 3h post-application. This study suggests that nano-sized emulsions significantly increase the bioavailability of transdermally applied delta tocopherol.

Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. Publishing Authors By Initials

T Kotyla,F Kuo,V Moolchandani,T Wilson,R Nicolosi,T Kotyla,F Kuo,V Moolchandani,T Wilson,R Nicolosi,

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Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of pharmaceutics

VOLUME: 347

Page Numbers: 144-8

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ISSN: 0378-5173

DAY: 4

MONTH: 07

YEAR: 2007

Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Increased bioavailability of a transdermal application of a nano-sized emulsion preparation.

AFFILIATION: Department of Clinical Laboratory and Nutritional Sciences, Center for Health and Disease Research, University of Massachusetts Lowell, Lowell, MA 01854, USA.

Country: Netherlands

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MEDLINETA: Int J Pharm

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