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Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver.

Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Research Abstract Details 

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  • Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Abstract Text:

    k kurodaK Kuroda,m hiroseM Hirose,m okadaM Okada,

    Cytosolic aspartate aminotransferase from rat liver was separated into at least 3 subforms, focused at pH 6.2, 5.9, and 5.7, by isoelectric focusing. Increase of subforms with low pI values was observed in pyridoxine-deficient rat liver. These subforms with low pI values showed low catalytic activities relative to their antigenic activities. The Km values for substrate and optimal pH values of the two main subforms were not significantly different in pyridoxine-deficient and control rat livers. Some conformational change of enzyme in the cytosol of pyridoxine-deficient rat liver was suggested by circular dichroic and fluorescent spectra. The N and C terminals of the enzyme from both pyridoxine-deficient rats and controls were shown to be alanine and glutamine, respectively.

    Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Publishing Authors By Initials

    k kurodaK Kuroda,m hiroseM Hirose,m okadaM Okada,

    For similar nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin b deficiency: vitamin b 6 deficiency research abstracts see: nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin b deficiency: vitamin b 6 deficiency research

    PUBMED ID PMID:

    MEDLINE DATE:

    Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of biochemistry

    VOLUME: 92

    Page Numbers: 1079-85

    Journal Abbreviation: J. Biochem.

    ISSN: 0021-924X

    DAY: 19

    MONTH: Oct

    YEAR: 1982

    Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 376600

    Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Keywords Mesh Terms:

    KEYWORDS: Vitamin B 6 Deficiency

    MESH TERMS: enzymology

    Chemical & Substance for Abstract: Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. Information

    Substance Name: Aspartate Aminotransferases

    Registry Number: EC 2.6.1.1

    Grant and Affiliation Information for Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver.

    AFFILIATION:

    Country: JAPAN

    JAPAN Research PublicationJAPAN Research Publication

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    MEDLINETA: J Biochem

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