Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide.

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Abstract Text:

M V Padma,Subhash Kaul,

BACKGROUND: Although the risk reduction of recurrent stroke with angiotensin converting enzyme-inhibitors with or without a diuretic has been demonstrated under randomized double blind conditions of the PROGRESS study, it is unclear whether the benefit is reflected in primary care practice and in populations with different demographic and clinical characteristics. AIM: To assess the effect and acceptability of perindopril with or without indapamide prevention of recurrent stroke, as reflected by its incidence. SETTING AND DESIGN: Multicentre, prospective, observational study in the setting of primary care throughout India. MATERIALS AND METHODS: Patients with a stable stroke or transient ischaemic attack (TIA) received a 12-month perindopril +/- indapamide-based regimen, similar to that used in PROGRESS. The principal outcome was the annual incidence of recurrent stroke. Statistical Analysis: Summary statistics and the Kaplan-Meier procedure. RESULTS: The mean age of 298 patients was 58.3 years (SD=12.6). 229 (77.5%) had an ischaemic stroke; 231 (77.5%) were hypertensive; 200 (85.5%) were receiving aspirin and 81 (27.2%) statins. During the 12-month perindopril-based treatment, there were 8 (2.7%) recurrent strokes, with a Kaplan-Meier estimate of strokes plus TIA of 3.3% (95% CI, 1.0-5.6). CONCLUSIONS: The incidence of recurrent stroke is similar to that observed under double blind randomized conditions in the treatment arm of the PROGRESS study. This suggests that perindopril +/- indapamide-based prevention may be effective in reducing risk of recurrent stroke, (although the uncontrolled study design does not actually demonstrate this), in the setting of day-to-day clinical practice and among patients with different demographic and clinical characteristics than the PROGRESS population.

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Publishing Authors By Initials

MV Padma,S Kaul,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurology India

VOLUME: 55

Page Numbers: 141-4

Journal Abbreviation:

ISSN: 0028-3886

DAY: 11

MONTH: 06

YEAR: 2007

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 42005

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide.

AFFILIATION: Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. drmvpadma@yahoo.com.

Country: India

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurol India

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide Related Publications

• 'Induction of inflammatory gene expression by THP-1 macrophages cultured in normocholesterolaemic hypertensive sera and modulatory effects of green tea polyphenols'.
• A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plants.
• Amlodipine induced gingival hyperplasia: a rare entity.
• COURAGE under fire: on the management of stable coronary disease.
• Closing gaps in the human genome with fosmid resources generated from multiple individuals.
• Cognitive rehabilitation in stroke : therapy and techniques.
• Coronin-1A epigenomics governs mycobacterial persistence in tuberculosis.
• Corticobasal syndrome due to a thalamic tuberculoma and focal cortical atrophy.
• Cost-effectiveness of high-dose atorvastatin compared with usual-dose simvastatin: less than IDEAL?
• Critical care management of acute stroke.
• Cyclic variation in ultrasonic myocardial integrated backscatter is due to phasic changes in the number of patent myocardial microvessels.
• EXTRACTION OF THORN FROM THE ORBITAL CAVITY.
• HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis.
• Hegira adaptation of the NCHS weight and height charts.
• Iatrogenic disease management: moderating medication errors and risks in a pharmacy benefit management environment.
• Incidence of recurrent stroke in primary care during preventive treatment based on perindopril with or without indapamide.
• Microbubbles and Ultrasound: A Bird's Eye View.
• Minimally invasive repair of traumatic right-sided diaphragmatic hernia with delayed diagnosis.
• Mucosal Innate Immunity as a Determinant of HIV Susceptibility.
• Phasic changes in arterial blood volume is influenced by collateral blood flow: implications for the quantification of coronary stenosis at rest.
• Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema.
• Prevention and treatment: a tale of two strategies.
• Scaling in the fan of an unconventional quantum critical point.
• Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion.
• Sternal bands for closure of midline sternotomy leads to better wound healing.
• Strike out stroke.
• Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow.
• The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy.
• Transmyocardial revascularization ameliorates ischemia by attenuating paradoxical catecholamine-induced vasoconstriction.
• [Nitroglycerine promotes myocardial oxygen metabolism and regional cardiac function in vivo]