Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine.

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Abstract Text:

BACKGROUND: We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV). METHODS: Individuals with SCD who were enrolled in Tennessee Medicaid from January 1995 through December 2004 were identified using SCD-specific International Classification of Diseases, Ninth Revision, Clinical Modification codes. Population-based surveillance data were used to identify individuals with IPD and were linked to patients with SCD in the Tennessee Medicaid database to determine incidence rates of IPD. Clinical data were collected on all subjects with IPD, and antibiotic susceptibility testing and serotyping were performed on all available pneumococcal isolates. RESULTS: We identified 2026 individuals with SCD, who constituted 13,687 person-years of follow-up. During the study period, 37 individuals with SCD developed IPD, and 21 of these patients were aged <5 years. In a comparison of the pre-PCV period (1995-1999) with the post-PCV period (2001-2004), the rate of IPD decreased by 90.8% in children aged <2 years (from 3630 to 335 cases per 100,000 person-years; P<.001) and by 93.4% in children aged <5 years (from 2044 to 134 cases per 100,000 person-years; P<.001). Rates of IPD for patients with SCD who were aged >or=5 years decreased from 161 cases per 100,000 person-years during the pre-PCV period to 99 cases per 100,000 person-years during the post-PCV period (P=.36). CONCLUSION: The rate of IPD among children with SCD who are aged <5 years has decreased markedly since the introduction of routine administration of PCV to young children.

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Publishing Authors By Initials

For similar vaccines, conjugate research abstracts see: vaccines, conjugate research

PUBMED ID PMID:

MEDLINE DATE:

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical infectious diseases : an official publica

VOLUME: 44

Page Numbers: 1428-33

Journal Abbreviation:

ISSN: 1537-6591

DAY: 18

MONTH: 04

YEAR: 2007

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9203213

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Keywords Mesh Terms:

KEYWORDS: Vaccines, Conjugate

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Information

Substance Name: Vaccines, Conjugate

Registry Number: 0

Grant and Affiliation Information for Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine.

AFFILIATION: Department of Pediatrics, Vanderbilt University School of Medicine, USA. Natasha.halasa@vanderbilt.edu

Country: United States

AGENCY: United States PHS

GRANT: U50/CCU416123

ACRONYM: RR

MEDLINETA: Clin Infect Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine Related Publications

• A field-sweep/field-lock system for superconducting magnets--Application to high-field EPR.
• Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
• Commercial aspects of bovine embryo transfer.
• Comparison of low versus high tacrolimus levels in kidney transplantation: assessment of efficacy by protocol biopsies.
• Description of depolarization effects in double-quantum solid state nuclear magnetic resonance experiments using multipole-multimode Floquet theory.
• Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.
• Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
• Equine fetal kinetics: Presentation and location.
• Eye movement, vection, and motion sickness with foveal and peripheral vision.
• Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination.
• High-density lipoprotein and the risk of recurrent venous thromboembolism.
• High-frequency dynamic nuclear polarization using mixtures of TEMPO and trityl radicals.
• Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry.
• In situ temperature jump high-frequency dynamic nuclear polarization experiments: enhanced sensitivity in liquid-state NMR spectroscopy.
• Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine.
• Increasing Stimulation Frequency Prolongs Force Output in Healthy Thenar Muscle: 1923: Board #211 10:30 AM- 10:30 AM.
• Interpreting treatment effects when cases are institutionalized after treatment.
• Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.
• Multipole-multimode Floquet theory of rotational resonance width experiments: 13C-13C distance measurements in uniformly labeled solids.
• Natural outcome and ultrasonic identification of equine fetal twins.
• Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
• Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry.
• Proton assisted insensitive nuclei cross polarization.
• Recovery and transfer of equine embryos.
• Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.
• Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide.
• Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance.
• Sustaining knowledge transfer through leadership.
• Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.
• TOTAPOL: a biradical polarizing agent for dynamic nuclear polarization experiments in aqueous media.