Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program.

Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program. Research Abstract Details 

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Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program. Abstract Text:

Reinaldo M Martins,Luiz A B Camacho,Maria Cristina F Lemos,Tatiana G de Noronha,Maria Helena C de Carvalho,Nadja Greffe,Marli M da Silva, ,Maria de Lourdes S Maia,Akira Homma,Reinaldo M Martins,Luiz A B Camacho,Maria Cristina F Lemos,Tatiana G de Noronha,Maria Helena C de Carvalho,Nadja Greffe,Marli M da Silva, ,Maria Lourdes S Maia,Akira Homma,Reinaldo M Martins,Luiz A B Camacho,Maria Cristina F Lemos,Tatiana G de Noronha,Maria Helena C de Carvalho,Nadja Greffe,Marli M da Silva,André R Périssé,Maria Lourdes S Maia,Akira Homma,

OBJECTIVE: To evaluate the safety of a combined diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine used on the Brazilian National Immunizations Program, chiefly the incidence of hypotonic-hyporesponsive episodes. METHOD: Follow-up of a cohort of 21,064 infants (20,925 or 99.7% adhered to the study protocol), within 48 hours of vaccination with diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine in health care units in the City of Rio de Janeiro, to ascertain and investigate spontaneous and solicited severe adverse events. Each child was followed-up for one dose only. RESULTS: The rate of hypotonic-hyporesponsive episodes was 1/1,744 doses (confirmed cases) and 1/1,495 doses (confirmed plus suspect cases). The rate of convulsions was 1/5,231 doses. No cases of apnea were detected. These results are comparable to those found in the literature with diphtheria-tetanus-whole cell pertussis vaccine. CONCLUSION: The diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine under study can be safely used in the National Immunizations Program, according to the current precautions and contraindications.

Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program. Publishing Authors By Initials

RM Martins,LA Camacho,MC Lemos,TG de Noronha,MH de Carvalho,N Greffe,MM da Silva,AR ,Mde Maia,A Homma,RM Martins,LA Camacho,MC Lemos,TG de Noronha,MH de Carvalho,N Greffe,MM da Silva,AR ,ML Maia,A Homma,RM Martins,LA Camacho,MC Lemos,TG de Noronha,MH de Carvalho,N Greffe,MM da Silva,AR Périssé,ML Maia,A Homma,

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PUBMED ID PMID:

MEDLINE DATE: 2007 Nov-Dec

Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Jornal de pediatria

VOLUME: 83

Page Numbers: 523-8

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ISSN: 0021-7557

DAY: 12

MONTH: 12

YEAR: 2007

Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program. Information

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LANGUAGE: eng

NlmUniqueID: 2985188

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Grant and Affiliation Information for Incidence of hypotonic-hyporesponsive episodes associated to the combined DTP/Hib vaccine used in Brazilian National Immunizations Program.

AFFILIATION: Fundação Oswaldo Cruz (Fiocruz), Manguinhos, RJ, Brazil.

Country: Brazil

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MEDLINETA: J Pediatr (Rio J)

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