Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment.

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Abstract Text:

AIMS/BACKGROUND: The introduction of the adjunctive use of antiproliferatives to trabeculectomy has greatly improved the success rate of this operation. Trabeculectomy with antiproliferative treatment, however, is usually associated with a cystic and thin walled filtering bleb, which may be more susceptible to infection. The objective of this study was to evaluate the incidence, clinical findings, and risk factors of delayed onset, bleb related infection after trabeculectomy with adjunctive mitomycin C (MMC) or 5-fluorouracil (5-FU) treatment. METHODS: The records of 632 glaucoma patients who underwent 966 trabeculectomies, with and without the use of adjunctive MMC or 5-FU treatment, between January 1985 and February 1995 were analysed. The mean follow up period was 3.5 (2.4) years (range 0.1 to 11.2 years). The mean patient age was 54.8 (18.8) years (range 0 to 88 years). RESULTS: Bleb related infection occurred in one of 76 trabeculectomies that did not receive antiproliferatives (1.3%), three of 228 treated with 5-FU (1.3%) trabeculectomies, and seven of 662 treated with MMC (1.1%). Five eyes developed blebitis; six eyes developed endophthalmitis. Bleb related infection developed an average of 3.1 (1.6) (range 0.4 to 6.0) years after trabeculectomy. All eyes had avascular or hypovascular blebs that were cystic in shape before infection and all eyes had reduced intraocular pressure. Early wound leaks and chronic, intermittent bleb leaks were identified to be risk factors for the bleb related infection. CONCLUSION: The incidence of delayed onset, bleb related infection after trabeculectomy with antiproliferative treatment is similar to that after trabeculectomy without antiproliferatives.

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 81

Page Numbers: 877-83

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Oct

YEAR: 1997

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 421041

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Keywords Mesh Terms:

KEYWORDS: Trabeculectomy

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment. Information

Substance Name: Fluorouracil

Registry Number: 51-21-8

Grant and Affiliation Information for Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment.

AFFILIATION: Department of Ophthalmology, Gifu University School of Medicine, Japan.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Ophthalmol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment Related Publications

• A new scoring system for comparing the results of high-pass resolution perimetry and differential light sensitivity perimetry in glaucoma patients.
• Accelerated recognition of left oblique views of faces.
• Application trials of in situ hybridization at the electron microscopic level.
• Contribution of Va24Vb11 natural killer T cells in Wilsonian hepatitis.
• Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels.
• Disc hemorrhage and peripapillary atrophy in apparently healthy subjects.
• Discovery of two rare species of stalked crinoids from okinawa trough, southwestern Japan, and their systematic and biogeographic implications.
• Effects of visual stimuli on temporal order judgments of unimanual finger stimuli.
• Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer.
• Estimated nutritional intake based on the reference growth curves for extremely low birthweight infants.
• Gastric remnant adenocarcinoma with micropapillary component.
• Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice.
• Incidence of delayed onset infection after trabeculectomy with adjunctive mitomycin C or 5-fluorouracil treatment.
• Influence of heart surgery on magnesium concentrations in pediatric patients.
• Invasive ductal breast carcinoma metastatic to uterus.
• Long-lasting aftereffects of prism adaptation in the monkey.
• Molecular Cloning and Functional Characterization of Porcine MyD88 Essential for TLR Signaling.
• Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.
• Neuronal activity related to anticipated and elapsed time in macaque supplementary eye field.
• Neuronal activity related to reward size and rewarded target position in primate supplementary eye field.
• Physiological significance of Ca uptake by mitochondria in the heart in comparison with that by cardiac sarcoplasmic reticulum.
• Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage.
• Referral of tactile stimuli to action points in virtual reality with reaction force.
• Specificity and sensitivity of glaucoma detection in the Japanese population using scanning laser polarimetry.
• Studies of magnesium in congenital long QT syndrome.
• T-138C polymorphism of matrix gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification.
• Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line.
• Wireless voltammetry recording in unanesthetised behaving rats.
• [Temporal order judgment in the brain]
• [Tubulointerstitial nephritis associated with drug reactions]