Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma.

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Abstract Text:

Takayuki Akasu,Masashi Takawa,Seiichiro Yamamoto,Shin Fujita,Yoshihiro Moriya,

BACKGROUND: The aim of this study was to evaluate the incidence and patterns of recurrence, or oncologic safety, after intersphincteric resection (ISR) without radiotherapy for very low rectal adenocarcinoma. STUDY DESIGN: One hundred eight consecutive patients with T1-T3 rectal cancers located 1 to 5 cm (median 3 cm) from the anal verge underwent ISR. A retrospective analysis of prospectively recorded data from the 106 patients not receiving radiotherapy was performed. RESULTS: There were 23 T1, 40 T2, and 43 T3 tumors. Morbidity and mortality rates were 33% and 1%, respectively. The 3-year rates of overall local recurrence and survival were 5.7% and 95%, respectively. The 3-year cumulative local recurrence rate was 0% for the patients with T1-T2 tumors as compared with 15% for those with T3 tumors (p=0.0012). In T3 tumors, the 2-year local recurrence rate was 5% for patients with negative surgical margins as compared with 33% for those with positive margins (p=0.0001). The incidences of distant recurrence for stages I, II, III, and IV disease were 4%, 5%, 18%, and 33%, respectively. CONCLUSIONS: ISR does not increase local or distant recurrences. For T1-T2 tumors, meticulous dissection and irrigation after closure of the distal stump allows local control without radiotherapy. With T3 tumors, preoperative therapy should be considered if resection margins are estimated to be insufficient.

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Publishing Authors By Initials

T Akasu,M Takawa,S Yamamoto,S Fujita,Y Moriya,

For similar investigative techniques: epidemiologic methods: statistics as topic: survival analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: survival analysis research

PUBMED ID PMID:

MEDLINE DATE:

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American College of Surgeons

VOLUME: 205

Page Numbers: 642-7

Journal Abbreviation: J. Am. Coll. Surg.

ISSN: 1072-7515

DAY: 14

MONTH: 09

YEAR: 2007

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9431305

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Keywords Mesh Terms:

KEYWORDS: Survival Analysis

MESH TERMS: surgery

Chemical & Substance for Abstract: Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma.

AFFILIATION: Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Coll Surg

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma Related Publications

• A paired study of Perthes' disease comparing conservative and surgical treatment.
• Analysis of surrogate markers for target-specific therapy in breast carcinomas using archival materials.
• Clinicopathological significance of fibrous tissue around fixed recurrent rectal cancer in the pelvis.
• Dorsal root ganglion neurones with dichotomising afferent fibres to both the lumbar disc and the groin skin. A possible neuronal mechanism underlying referred groin pain in lower lumbar disc diseases.
• Fracture-dislocation of the fifth lumbar vertebra. A new classification.
• Impact of upward lymph node dissection on survival rates in advanced lower rectal carcinoma.
• Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma.
• Interleukin-8 Production from Human Umbilical Vein Endothelial Cells During Brief Hyperglycemia: The Effect of Tumor Necrotic Factor-alpha.
• Intervertebral disc degeneration associated with lumbosacral transitional vertebrae: a clinical and anatomical study.
• Intracrinology of estrogens and androgens in breast carcinoma.
• Irregularity of medial femoral condyle on MR imaging serves as a possible indicator of objective severity of medial-type osteoarthritic knee-a pilot study.
• Isolation and some properties of dog and rat pancreatic kallikreins.
• Kallikrein inhibitors in rat plasma.
• Laparoscopic resection for malignant lymphoma of the ileum causing ileocecal intussusception.
• MRI study of talonavicular alignment in club foot.
• Natural history of infantile tibia vara.
• Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity.
• Sensory nerve fibres from lumbar intervertebral discs pass through rami communicantes. A possible pathway for discogenic low back pain.
• Studies of enzyme-catalyzed modification of proteins. I. Tyrosinase-catalyzed modification of asparaginase.
• Studies on human salivary kallikrein. II. Properties of purified salivary kallikrein.
• Studies on kallikrein inhibitors from potatoes. IV. Isolation of two inhibitors and determination of molecular weights and amino acid compositions.
• Studies on kallikrein inhibitors from potatoes. V. Characterization of two isolated inhibitors.
• The afferent pathways of discogenic low-back pain. Evaluation of L2 spinal nerve infiltration.
• The effects of radial shock waves on gene transfer in rabbit chondrocytes in vitro.
• The knee-spine syndrome. Association between lumbar lordosis and extension of the knee.
• Ultrastructure of the chick vestibular ganglion and vestibular nucleus. A scanning electron microscopic study.
• Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain.
• Visualisation of symptomatic nerve roots. Prospective study of contrast-enhanced MRI in patients with lumbar disc herniation.
• Wound infection after elective laparoscopic surgery for colorectal carcinoma.
• [Practice of exercise therapy for allergic children--bronchial asthma]