Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Abstract Text:

Myoung Ja Chung,Sung Hoo Jung,Bong Ju Lee,Myoung Jae Kang,Dong Geun Lee,Myoung Ja Chung,Sung Hoo Jung,Bong Ju Lee,Myoung Jae Kang,Dong Geun Lee,

PTEN is a novel tumor-suppressor gene located on chromosomal band 10q23. Loss of PTEN function has been implicated in the progression of several types of cancer, but the correlation between loss of PTEN expression and advanced carcinomas is not well established. The capacity for angiogenesis of a tumor is known to play a very important role in growth and metastasis, and there have been reports that PTEN relates to angiogenesis. In the present study, formalin-fixed and paraffin embedded tissues from 101 patients with breast carcinomas, including 88 cases of invasive ductal carcinomas and 13 cases of ductal carcinoma in situ (DCIS), were evaluated by immunohistochemical methods for the expression of PTEN and vascular endothelial growth factor (VEGF), as well as microvessel density (MVD). The results were compared with the clinicopathologic parameters. There was no loss of PTEN expression in any of the cases of DCIS, but 28 (32%) of the 88 invasive cases did not express PTEN. Loss of PTEN expression was associated with lymph node metastasis (P = 0.03), but did not correlate with tumor size, tumor grade, MVD or recurrence. VEGF expression significantly correlated with lymph node metastasis in invasive ductal carcinoma (P = 0.01). There was no correlation between the expression of PTEN and that of VEGF (P = 0.63). The present study suggests that loss of PTEN expression is common and correlates with tumor progression and lymph node metastasis in breast carcinoma. The relationship between loss of PTEN and progression of breast cancer may not be explained by modulation of angiogenesis.

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Publishing Authors By Initials

MJ Chung,SH Jung,BJ Lee,MJ Kang,DG Lee,MJ Chung,SH Jung,BJ Lee,MJ Kang,DG Lee,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pathology international

VOLUME: 54

Page Numbers: 10-5

Journal Abbreviation: Pathol. Int.

ISSN: 1320-5463

DAY: 16

MONTH: Jan

YEAR: 2004

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9431380

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.

AFFILIATION: Departments of Pathology and General Surgery, Chonbuk National University Medical School, Institute for Medical Sciences, Jeonju and Department of Obstetric and Gynecology, Wonkwang University, Iksan, Korea.

Country: Australia

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pathol Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer Related Publications

• A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.
• Actual Conditions and Countermeasure of Yun-bian Old Men's Health.
• Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.
• Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells.
• Channel architecture in maltoporin: dominance studies with lamB mutations influencing maltodextrin binding provide evidence for independent selectivity filters in each subunit.
• Compensation. Costly to a fault.
• Design and feasibility of quick EXAFS scans for a 'broomstick' double-crystal monochromator at PLS beamline.
• Directed evolution of the lambda receptor of Escherichia coli through affinity chromatographic selection.
• Effects of dietary vitamin E supplementation on lipid oxidation and volatiles content of irradiated, cooked turkey meat patties with different packaging.
• Exclusion of high-molecular-weight maltosaccharides by lipopolysaccharide O-antigen of Escherichia coli and Salmonella typhimurium.
• Family decision making for elderly patients in the intensive care unit.
• Identification of an osteogenic protein-1 responsive element in the aggrecan promoter.
• Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.
• Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.
• Isolation, by affinity chromatography, of mutant escherichia coli cells with novel regulation of lamB expression.
• Longitudinal clivus fracture associated with trapped basilar artery: unusual survival with good neurological recovery.
• MPer1 and mper2 are essential for normal resetting of the circadian clock.
• Model construction on quality of family caregiving in the elderly.
• Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
• Photoionization studies of sulfur radicals and products of their reactions.
• Posterior transarticular screw fixation for chronic atlanto-axial instability.
• Reciprocal regulation of haem biosynthesis and the circadian clock in mammals.
• Restoration of a loose implant supported crown: a case report.
• Significance of chronic epilepsy in glial tumors and correlation with surgical strategies.
• The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
• The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.
• The influence of maltoporin affinity on the transport of maltose and maltohexaose into Escherichia coli.
• Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.
• Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.
• [Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition]