Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions.

Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Research Abstract Details 

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Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Abstract Text:

K Kato,M Kobayashi,S Sato,

The regulatory mechanism of a phosphoprotein phosphatase (EC 3.1.3.16), which is considered to catalyze the dephosphorylation reaction of several phosphoproteins (glycogen synthetase-D (EC 2.4.1.11), phospho-form of phosphorylase b kinase (EC 2.7.1.38), phosphohistone and phosphorylase a (EC 2.4.1.1)), was studied with partially purified preparations from rabbit skeletal muscle. Time- and temperature-dependent inactivation and reactivation of phosphohistone phosphatase, as well as phosphorylase phosphatase (EC 3.1.3.17), were observed on pre0incubation of the enzyme(s) with ATP, and subsequent incubation with divalent metal ions (Mg2+, Mn2+, or Co2+) without any change of molecular size. Manganese, however, instantly restored the activity of the ATP-inactivated enzyme, and increased the maximal velocity of the enzyme while decreasing its affinity to phosphorylase a. However, the metal ion inhibited the reactivated enzyme competively with respect to phosphorylase a. It is suggested that phosphoprotein phosphatase(s) is a metalloenzyme, and that ATP results in a conformational change of the enzyme protein in such a way that a metal ion can be easily released due to the chelating effect of ATP, or incorporated (in the presence of excess metal ions) into the enzyme protein.

Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Publishing Authors By Initials

K Kato,M Kobayashi,S Sato,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 77

Page Numbers: 811-5

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Apr

YEAR: 1975

Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inactivation and reactivation of phosphoprotein phosphatase of rabbit skeletal muscle. Role of ATP and divalent metal ions. Information

Substance Name: Phosphoric Monoester Hydrolases

Registry Number: EC 3.1.3.-

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Country: JAPAN

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MEDLINETA: J Biochem

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