Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Research Abstract Details 

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Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Abstract Text:

Steven A Rosenberg,James C Yang,Richard M Sherry,Patrick Hwu,Suzanne L Topalian,Douglas J Schwartzentruber,Nicholas P Restifo,Leah R Haworth,Claudia A Seipp,Linda J Freezer,Kathleen E Morton,Sharon A Mavroukakis,Donald E White,

Immunization with plasmid DNA represents a theoretically attractive method for increasing T cell responses against cancer antigens. We administered plasmid DNA encoding the gp100 melanoma-melanocyte differentiation antigen to 22 patients with metastatic melanoma and evaluated immunologic and clinical responses. Patients were randomized to receive plasmid DNA either intradermally (n = 10) or intramuscularly (n = 12). One patient (4.5%) exhibited a partial response of several subcentimeter cutaneous nodules. All other patients had progressive disease. Of 13 patients with cells available before and after immunization, no patient exhibited evidence of the development of anti-gp100 cell responses using in vitro boost assays. The same assays were capable of demonstrating immunologic precursors after immunization with fowl poxvirus encoding gp100 or with gp100 peptides. We were thus unable to demonstrate significant clinical or immunologic responses to plasmid DNA encoding the "self" nonmutated gp100 tumor antigen.

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Publishing Authors By Initials

SA Rosenberg,JC Yang,RM Sherry,P Hwu,SL Topalian,DJ Schwartzentruber,NP Restifo,LR Haworth,CA Seipp,LJ Freezer,KE Morton,SA Mavroukakis,DE White,

For similar proteins: recombinant proteins: vaccines, synthetic: vaccines, dna research abstracts see: proteins: recombinant proteins: vaccines, synthetic: vaccines, dna research

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Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Human gene therapy

VOLUME: 14

Page Numbers: 709-14

Journal Abbreviation: Hum. Gene Ther.

ISSN: 1043-0342

DAY: 20

MONTH: May

YEAR: 2003

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Information

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LANGUAGE: eng

NlmUniqueID: 9008950

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Keywords Mesh Terms:

KEYWORDS: Vaccines, DNA

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Information

Substance Name: melanocyte lineage-specific antigen gp10

Registry Number: 0

Grant and Affiliation Information for Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.

AFFILIATION: Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA. sar@nih.gov

Country: United States

AGENCY: United States NCI

GRANT: Z01 BC010763-01

ACRONYM: BC

MEDLINETA: Hum Gene Ther

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