In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition.

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Abstract Text:

Manuel ,Victoriano ,Odile Bunoust, Manon,Michel Rigoulet,Salvador Uribe,Manuel ,Victoriano ,Odile Bunoust, Manon,Michel Rigoulet,Salvador Uribe,

In yeast, Ca(2+) and long chain alkylguanidines interact with mitochondria modulating the opening of the yeast mitochondrial unspecific channel. Mammalians possess a similar structure, the mitochondrial permeability transition pore. The composition of these pores is under debate. Among other components, the voltage-dependent anion channel has been proposed as a component of either pore. In yeast from an industrial strain, octylguanidine and calcium closed the yeast mitochondrial unspecific channel. Here, the effects of the cations Ca(2+) or octylguanidine and the voltage-dependent anion channel effector decavanadate were evaluated in yeast mitochondria from either a wild type or a voltage-dependent anion channel deletion laboratory strain. It was observed that in the absence of voltage-dependent anion channel, the yeast mitochondrial unspecific channel was desensitized to Ca(2+), octylguanidine or decavanadate but remained sensitive to phosphate. It is thus suggested that in yeast mitochondria, the voltage-dependent anion channel has a cation binding site where Ca(2+) and octylguanidine interact, conferring cation sensitivity to the yeast mitochondrial unspecific channel.

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Publishing Authors By Initials

M ,V ,O Bunoust,S Manon,M Rigoulet,S Uribe,M ,V ,O Bunoust,S Manon,M Rigoulet,S Uribe,

For similar proteins: carrier proteins: membrane transport proteins: ion channels: porins: voltage-dependent anion channels research abstracts see: proteins: carrier proteins: membrane transport proteins: ion channels: porins: voltage-dependent anion channels research

PUBMED ID PMID:

MEDLINE DATE:

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochimica et biophysica acta

VOLUME: 1767

Page Numbers: 1245-51

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 19

MONTH: 07

YEAR: 2007

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Keywords Mesh Terms:

KEYWORDS: Voltage-Dependent Anion Channels

MESH TERMS: metabolism

Chemical & Substance for Abstract: In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition.

AFFILIATION: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D. F., Mexico.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochim Biophys Acta

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

In yeast, Ca2+ and octylguanidine interact with porin VDAC preventing the mitochondrial permeability transition Related Publications

• A review of the pathogenesis of ankylosing spondylitis.
• Adiponectin, structure, function and pathophysiological implications in non-alcoholic fatty liver disease.
• Anabolic-androgenic steroids and liver injury.
• Comparative study of the transverse strength of three denture base materials.
• Effect of Helicobacter pylori infection on gastric ghrelin expression and body weight.
• Effects of ursodeoxycholic acid on hemodynamic and renal function abnormalities induced by obstructive jaundice in rats.
• Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients.
• Flexion-distraction injury of the L1 vertebra treated with short-segment posterior fixation and Optimesh.
• Gallstones are associated with carotid atherosclerosis.
• Hepatocellular carcinoma in hispanics.
• In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition.
• Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus).
• Internal validity of a household food security scale is consistent among diverse populations participating in a food supplement program in Colombia.
• Intestinal flora, probiotics, and cirrhosis.
• Microscopic colitides: a single center experience in Mexico.
• Normative study of tympanic infrared thermometry: a non-invasive index of asymmetric cerebral activity.
• Pathophysiology of ascites and dilutional hyponatremia: Contemporary use of aquaretic agents.
• Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis.
• Prolonged effect of a mother-child caries preventive program on dental caries in the permanent 1st molars in 9 to 10-year-old children.
• Protection of the gastroduodenal mucosa by prostaglandins.
• Sorafenib, a systemic therapy for hepatocellular carcinoma.
• The molecular basis of susceptibility to infection in liver cirrhosis.
• Treating nonalcoholic fatty liver disease.
• Triple combination of thymalfasin, peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior interferon and ribavirin treatment: 24-week interim results of a pilot study.
• [Congenital hemolytic anemia and pregnancy; report of a case and review of the literature.]
• [Critical analysis of awards in gastroenterology research. The Mexican experience]
• [From the mechanical complexity in biology]
• [Not Available.]
• [Rhabdomyomatous mesenchymal hamartoma.]
• [THE LESION OF MONTEGGIA.]