In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development.

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Research Abstract Details 

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In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Abstract Text:

Brandon B Kirby,Norio Takada,Andrew J Latimer,Jimann Shin,Thomas J Carney,Robert N Kelsh,Bruce Appel,

Myelinating oligodendrocytes arise from migratory and proliferative oligodendrocyte progenitor cells (OPCs). Complete myelination requires that oligodendrocytes be uniformly distributed and form numerous, periodically spaced membrane sheaths along the entire length of target axons. Mechanisms that determine spacing of oligodendrocytes and their myelinating processes are not known. Using in vivo time-lapse confocal microscopy, we show that zebrafish OPCs continuously extend and retract numerous filopodium-like processes as they migrate and settle into their final positions. Process remodeling and migration paths are highly variable and seem to be influenced by contact with neighboring OPCs. After laser ablation of oligodendrocyte-lineage cells, nearby OPCs divide more frequently, orient processes toward the ablated cells and migrate to fill the unoccupied space. Thus, process activity before axon wrapping might serve as a surveillance mechanism by which OPCs determine the presence or absence of nearby oligodendrocyte-lineage cells, facilitating uniform spacing of oligodendrocytes and complete myelination.

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Publishing Authors By Initials

BB Kirby,N Takada,AJ Latimer,J Shin,TJ Carney,RN Kelsh,B Appel,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature neuroscience

VOLUME: 9

Page Numbers: 1506-11

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 12

MONTH: 11

YEAR: 2006

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Information

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LANGUAGE: eng

NlmUniqueID: 9809671

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: cytology

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Grant and Affiliation Information for In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development.

AFFILIATION: Department of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37232, USA.

Country: United States

AGENCY: United States CSR

GRANT: RG 3420

ACRONYM: RG

MEDLINETA: Nat Neurosci

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