In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography.

In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Research Abstract Details 

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In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Abstract Text:

Stephanie K Carlson,Kelly L Classic,Elizabeth M Hadac,Claire E Bender,Bradley J Kemp,Val J Lowe,Tanya L Hoskin,Stephen J Russell,

PURPOSE: This study was undertaken to determine the ability of micro-single photon emission computed tomography (micro-SPECT)/computed tomography (CT) to accurately quantitate intratumoral radioisotope uptake in vivo and to compare these measurements with planar imaging and micro-SPECT imaging alone. PROCEDURES: Human pancreatic cancer xenografts were established in 10 mice. Intratumoral radioisotope uptake was achieved via intratumoral injection of an attenuated measles virus vector expressing the NIS gene (MV-NIS). On various days after MV-NIS injection, (123)I planar and micro-SPECT/CT imaging was performed. Tumor activity was determined by dose calibrator measurements and region-of-interest (ROI) image analysis. Agreement and reproducibility of tumor activity measurements were assessed by Bland-Altman plots and Lin's concordance correlation coefficient (CCC). RESULTS: Intratumoral radioisotope uptake was detected in all mice. Scatterplots demonstrate strong agreement (CCC = 0.93) between micro-SPECT/CT ROI image analysis and dose calibrator tumor activity measurements. The differences between dose calibrator activity measurements and those obtained with ROI image analysis of micro-SPECT alone and planar imaging are less accurate and more variable (CCC = 0.84 and 0.78, respectively). CONCLUSIONS: Micro-SPECT/CT can be used to accurately quantify intratumoral radioisotope uptake in vivo and is more reliable than planar or micro-SPECT imaging alone.

In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Publishing Authors By Initials

SK Carlson,KL Classic,EM Hadac,CE Bender,BJ Kemp,VJ Lowe,TL Hoskin,SJ Russell,

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In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular imaging and biology : MIB : the official

VOLUME: 8

Page Numbers: 324-32

Journal Abbreviation:

ISSN: 1536-1632

DAY: 3

MONTH: 12

YEAR: 2007

In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101125610

In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: standards

Chemical & Substance for Abstract: In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. Information

Substance Name: Iodine Radioisotopes

Registry Number: 0

Grant and Affiliation Information for In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography.

AFFILIATION: Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 559005, USA. scarlson@mayo.edu

Country: United States

AGENCY: United States NCI

GRANT: K08 CA103859-01A1

ACRONYM: CA

MEDLINETA: Mol Imaging Biol

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