In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging.

In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Research Abstract Details 

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In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Abstract Text:

Joshua D Auerbach,Wade Johannessen,Arijitt Borthakur,Andrew J Wheaton,Carol A Dolinskas,Richard A Balderston,Ravinder Reddy,Dawn M Elliott,

Diagnostic methods and biomarkers of early disc degeneration are needed as emerging treatment technologies develop (e.g., nucleus replacement, total disc arthroplasty, cell therapy, growth factor therapy) to serve as an alternative to lumbar spine fusion in treatment of low back pain. We have recently demonstrated in cadaveric human discs an MR imaging and analysis technique, spin-lock T(1rho)-weighted MRI, which may provide a quantitative, objective, and non-invasive assessment of disc degeneration. The goal of the present study was to assess the feasibility of using T(1rho) MRI in vivo to detect intervertebral disc degeneration. We evaluated ten asymptomatic 40-60-year-old subjects. Each subject was imaged on a 1.5 T whole-body clinical MR scanner. Mean T(1rho) values from a circular region of interest in the center of the nucleus pulposus were calculated from maps generated from a series of T(1rho)-weighted images. The degenerative grade of each lumbar disc was assessed from conventional T(2)-weighted images according to the Pfirmann classification system. The T(1rho) relaxation correlated significantly with disc degeneration (r=-0.51, P<0.01) and the values were consistent with our previous cadaveric study, in which we demonstrated correlation between T(1rho) and proteoglycan content. The technique allows for spatial measurements on a continuous rather than an integer-based scale, minimizes the potential for observer bias, has a greater dynamic range than T(2)-weighted imaging, and can be implemented on a 1.5 T clinical scanner without significant hardware modifications. Thus, there is a strong potential to use T(1rho) in vivo as a non-invasive biomarker of proteoglycan loss and early disc degeneration.

In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Publishing Authors By Initials

JD Auerbach,W Johannessen,A Borthakur,AJ Wheaton,CA Dolinskas,RA Balderston,R Reddy,DM Elliott,

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In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: European spine journal : official publication of t

VOLUME: 15 Suppl 3

Page Numbers: S338-44

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ISSN: 0940-6719

DAY: 22

MONTH: 03

YEAR: 2006

In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Information

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LANGUAGE: eng

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Grant and Affiliation Information for In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging.

AFFILIATION: Department of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, Philadelphia, PA 19104-6081, USA.

Country: Germany

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MEDLINETA: Eur Spine J

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