In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent.

In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Research Abstract Details 

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In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Abstract Text:

, Kiss,Balazs Ruzsics,Brigitta C Brott, Simor,Ada Elgavish,Robert A Baker,Nada H Saab-Ismail,Gabriel A Elgavish,

The phenomenological tissue kinetics of Gd(ABE-DTTA) was investigated in myocardial infarction (MI). Reperfused infarction was generated by balloon catheter in closed-chest canines (N=11). Forty-eight hours thereafter, inversion-recovery (IR)-prepared fast gradient-echo control images were acquired with varying inversion times (TIs). Precontrast R(1) maps were calculated from the TI dependence of signal intensity (SI) using nonlinear curve fitting. Then 0.05 mmol/kg Gd(ABE-DTTA) was administered I.V. In 11 dogs postcontrast R(1) maps were generated at 24 hr and 48 hr postcontrast. In five dogs measurements were also repeated at 108 hr and 12 days. In one dog early measurement was carried out at 4 hr. Delta R(1) values for blood and viable and infarcted myocardium were calculated at each time point by subtracting the precontrast R(1) from the postcontrast R(1). Gd(ABE-DTTA) showed significant, progressive accumulation into infarcts during the first 2 days (k(in)=0.39 hr(-1)) and a delayed clearance (k(out) = 0.005 hr(-1)). Among the time points sampled, the maximum infarct Delta R(1) was detected at 48 hr (1.72 s(-1)). Contrast agent (CA) in infarcted tissue was detectable for 12 days. Clearance from blood and viable myocardium occurred in parallel and was completed by 108 hr. Gd(ABE-DTTA) displays slow, tissue-persistent kinetics and partly intravascular, partly extravascular characteristics. It demonstrates high affinity for infarcted myocardium and induces highlighting of infarcts between 4 hr and 12 days following administration.

In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Publishing Authors By Initials

P ,P Kiss,B Ruzsics,BC Brott,T Simor,A Elgavish,RA Baker,NH Saab-Ismail,GA Elgavish,

For similar organic chemicals: amines: polyamines: pentetic acid research abstracts see: organic chemicals: amines: polyamines: pentetic acid research

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In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Magnetic resonance in medicine : official journal

VOLUME: 58

Page Numbers: 55-64

Journal Abbreviation:

ISSN: 0740-3194

DAY: 3

MONTH: Jul

YEAR: 2007

In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8505245

In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Keywords Mesh Terms:

KEYWORDS: Pentetic Acid

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Information

Substance Name: Pentetic Acid

Registry Number: 67-43-6

Grant and Affiliation Information for In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent.

AFFILIATION: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R44 HL58285,

ACRONYM: HL

MEDLINETA: Magn Reson Med

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