In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Research Abstract Details 

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In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Abstract Text:

Arijitt Borthakur,Tamar Gur,Andrew J Wheaton,Matthew Corbo,John Q Trojanowski,Virginia M-Y Lee,Ravinder Reddy,

PURPOSE: To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain. MATERIALS AND METHODS: We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps. RESULTS: A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals. CONCLUSION: T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice.

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Publishing Authors By Initials

A Borthakur,T Gur,AJ Wheaton,M Corbo,JQ Trojanowski,VM Lee,R Reddy,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 24

Page Numbers: 1011-7

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Nov

YEAR: 2006

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 9105850

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: pathology

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Grant and Affiliation Information for In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.

AFFILIATION: Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA. ari@mail.mmrrcc.upenn.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR02305

ACRONYM: RR

MEDLINETA: J Magn Reson Imaging

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