In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease.

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Abstract Text:

Aminopyrine, antipyrine and trimethadione have been widely used for some time as probe drugs to assess non-selective P450 liver function. They have proved useful in evaluating pre- and post-operative liver function when performing surgery, transplantations, etc., in addition to a general evaluation of liver function and drug interactions. Progress has recently been made both in these non-selective P450 function tests and in the analysis of drug-metabolizing enzymes at a molecular level, which has resulted in more selective P450 function tests. The caffeine (CYP1 A2), chlorzoxazone (CYP2E1), lidocaine (CYP3 A) and midazolam (CYP3 A) function tests and the erythromycin breath test (CYP3 A) are currently being used as specific probes. The future use of these tests needs to be discussed in terms of potential clinical implications.

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: oxazoles: trimethadione research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: oxazoles: trimethadione research

PUBMED ID PMID:

MEDLINE DATE:

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 22

Page Numbers: 237-49

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Aug

YEAR: 1997

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Information

Number of References: 102

LANGUAGE: eng

NlmUniqueID: 8704308

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Keywords Mesh Terms:

KEYWORDS: Trimethadione

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Information

Substance Name: Cytochrome P-450 CYP2E1

Registry Number: EC 1.14.14.1

Grant and Affiliation Information for In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease.

AFFILIATION: Institute of Community Medicine, University of Tsukuba, Japan.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Pharm Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease Related Publications

• Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats.
• An MboI polymorphism at codon 192 of the human tyrosinase gene is present in Asians and Afrocaribbeans.
• Assay of midazolam and brotizolam in plasma by a gas chromatographic and a radioreceptor technique.
• Characterization of the humoral immune response in two paediatric patients transplanted with split livers from ABO-incompatible living-related donors: appearance of cytomegalovirus-induced ABO antibodies.
• Determination of glutathione in biological material by high pressure liquid chromatography.
• Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects.
• Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.
• Glycolipid Studies in Small Intestine and Pancreas of alpha1,3-Galactosyltransferase Knockout Miniature Swine: alpha1,3GALT-KO Animals Lack alphaGAL Antigens and Contain Novel Blood Group H Compounds.
• Glycosphingolipids of human large intestine: detailed structural characterization with special reference to blood group compounds and bacterial receptor structures.
• In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease.
• Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats.
• Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio.
• Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy.
• Pharmacokinetics in liver disease.
• Pharmacokinetics of temazepam compared with other benzodiazepine hypnotics--some clinical consequences.
• Pharmacology in The Netherlands: past, present and future.
• Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats.
• Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.
• Research in the Division of Pharmacology.
• Structural characterization of non-acid glycosphingolipids in kidneys of single blood group O and A pigs.
• Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature swine.
• Variability in drug metabolism: importance of genetic constitution.