In vivo DTI evaluation of white matter tracts in rat spinal cord.

In vivo DTI evaluation of white matter tracts in rat spinal cord. Research Abstract Details 

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In vivo DTI evaluation of white matter tracts in rat spinal cord. Abstract Text:

Jayaroop Gullapalli,Jaroslaw Krejza,Eric D Schwartz,

PURPOSE: To determine whether differences in specific spinal cord white matter (WM) tracts can be detected with in vivo DTI. MATERIALS AND METHODS: In vivo DTI was performed on six rats at the lower thoracic region using a 4.7T magnet. Axial diffusion images were obtained with diffusion gradients applied in six independent directions, with low and high b-values equal to 0 and 692 seconds/mm(2), respectively. Regions of interest (ROIs) were selected corresponding to the major spinal cord tracts, including the dorsal cortical spinal tract (dCST), fasciculus gracilis (FG), rubrospinal tract (RST), vestibulospinal tract (VST), and reticulospinal tract (ReST). RESULTS: ANOVA demonstrated overall differences between tracts for all of the DTI parameters, including fractional anisotropy (FA), trace diffusion (Tr), longitudinal diffusivity (EL = lambda(1)), and transverse diffusivity (ET = (lambda(2) + lambda(3))/2). Similarly to previous ex vivo analyses, the spinal cord tract with the largest and most widely spaced axons (VST) had the largest EL and ET. CONCLUSION: The principal diffusivities appear to reflect axon morphologic differences between the WM tracts that are not as well appreciated with FA and Tr.

In vivo DTI evaluation of white matter tracts in rat spinal cord. Publishing Authors By Initials

J Gullapalli,J Krejza,ED Schwartz,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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In vivo DTI evaluation of white matter tracts in rat spinal cord. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 24

Page Numbers: 231-4

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Jul

YEAR: 2006

In vivo DTI evaluation of white matter tracts in rat spinal cord. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

In vivo DTI evaluation of white matter tracts in rat spinal cord. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: pathology

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Grant and Affiliation Information for In vivo DTI evaluation of white matter tracts in rat spinal cord.

AFFILIATION: Department of Radiology, Neuroradiology Section, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS41380

ACRONYM: NS

MEDLINETA: J Magn Reson Imaging

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