In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits.

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Abstract Text:

Li-Chao Zhang,Jin-Hong Hu,Ling Li,Li-Hong Gao,Quan-Gang Zhu,Zhen Li,Zhong-Zhuang Wang,Ding-Feng Su,

The present study was designed to evaluate skin permeation enhancement effect of essential oils from Ligusticum chuanxiong HORT (chuanxiong oil) in rabbits and to compare the in vivo absorption and in vitro permeation using flurbiprofen as a model drug. In vivo results demonstrated that chuanxiong oil showed a rapid and marked permeation enhancement effect. The group with 10% oil exhibited the highest value of area under the curve (AUC) of 418+/-124 mug/ml.h, which was 2.43 times the high of control. The AUC value of 3% oil group (245+/-81.6 mug/ml.h) was similar to that of 5% oleic acid group (235+/-74.5 mug/ml.h). Whereas in vitro results indicated the enhancement of chuanxiong oil was relatively weak. The group with 3% oil appeared to the highest flurbiprofen flux (84.9+/-19.3 mug/cm(2)/h), to some extent lower than 5% oleic acid group (107+/-5.85 mug/cm(2)/h). At 10% and 15% concentrations, chuanxiong oil even decreased the flux of flurbiprofen compared with the control. Both in vitro results with pretreated skin and flurbiprofen content accumulated in skin indicated the potential mechanism for the in vitro enhancement of chuanxiong oil was the weakened barrier function by improving in the partitioning of flurbiprofen to the stratum corneum. The discrepancy was noted between the in vivo and in vitro results, indicating only about the weakened barrier function was not enough to explain the sharply increment of in vivo absorption of flurbiprofen by chuanxiong oil. The GS-MS results indicated phthalides identified from chuanxiong oil might mainly contribute to enhance in vivo absorption of flurbiprofen because of its large quantities (91.15%).

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Publishing Authors By Initials

LC Zhang,JH Hu,L Li,LH Gao,QG Zhu,Z Li,ZZ Wang,DF Su,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 29

Page Numbers: 1217-22

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 6

MONTH: Jun

YEAR: 2006

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9311984

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits.

AFFILIATION: Department of Pharmacy, Changhai Hospital, Second Military Medical University, P.R. China.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biol Pharm Bull

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits Related Publications

• Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes.
• Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.
• Hepatitis C in pregnancy.
• In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits.
• Study on relationship between carbon disulfide exposure and symptoms and signs of nervous system in workers.
• [A study on training method for increasing adaptability to blood redistribution in human]
• [Age-related and menopause-related changes of urinary excretion of C- and N-terminal cross-linked telopeptides of type I collagen and the relationships thereof with menopause-related bone loss]
• [Angiotensin II contents in plasma, and cardiac and renal tissues of sinoaortic denervated rats]
• [Characteristics and therapeutic strategies of nosocomial pneumonia in postoperative patients with acute hypertensive intracerebral hemorrhage]
• [Effect of different methods for postoperative pain management on catecholamine response to abdominal surgery]
• [Effect of early exposure to allergen on rat asthmatic model]
• [Effect of temperature of fluid infusion on diamine oxidase, MB isoenzyme of creatine kinase, creatine-kinase and lactate dehydrogenase in hemorrhagic shock rabbits.]
• [Genetic polymorphism of 6 short tandem repeat loci in Mongolian population of China]
• [Identification of a novel B variant allele in a Chinese Han individual with B subgroup]
• [Past, present and future development of the project of manned space medico-engineering in China]
• [Progress in research on forest tree genomics]
• [Quick determination of lubricating oil additive by infrared spectrum method]
• [Research on the nonlinear model of near infrared spectroscopy and the total sugar of tobacco samples]
• [Separation of soybean agglutinin by hydrophobic-interaction chromatography]
• [Single nucleotide polymorphisms of genes associated with high density lipoprotein metabolism in Chinese population]
• [Smoking and subjective life qualities in middle school students]
• [Soft tissue treatment and esthetic effect in dental implantation surgery]
• [Studies on the chemical constituents of the alga Sargassum carpophyllum J. Agardh]
• [Study of genetic polymorphism of 6 short tandem repeat loci in Nongqu Mongolian of inner Mongolia Autonomous Region in China]
• [Study on quality of crude Ramulas Cinnamomi in different reserve period and their prepared products]
• [Study on the steroid constituents of soft coral Lobophytum microspiculatum]
• [The improvement of sample preparation for infrared spectroscopy analysis]
• [Therapeutic efficiency of nitric oxide synthase inhibitor on traumatic shock in rats]
• [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]
• [Ye shes dpal'byor and Gan lu si bu (The four Tantras of nectar)]