In vitro studies on the putative function of N-acetylaspartate as an osmoregulator.

In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Research Abstract Details 

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In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Abstract Text:

Mattias Tranberg,Abdul-Karim Abbas,Mats Sandberg,

Efflux and tissue content of N-acetylaspartate (NAA) and amino acids were evaluated from cultured and acutely prepared hippocampal slices in response to changes in osmolarity. The osmoregulator taurine, but not NAA, was lost from both types of slices after moderate reductions in extracellular osmolarity (-60 mOsm) for 10-48 h. Hypoosmotic shock (-166 mOsm) for 5 min resulted in unselective efflux of several amino acids from acutely prepared slices. Notably, the efflux of taurine, but not NAA, was prominent also after the shock. Efflux of NAA was markedly enhanced by NMDA and high K(+), in particular after the stimulation period. The high K(+)-mediated efflux was decreased by high extracellular osmolarity and a NMDA-receptor antagonist. The results indicate that NAA efflux can be induced by a sudden non-physiological decrease in extracellular osmolarity but not by prolonged more moderate changes in osmolarity. The mechanisms behind the efflux of NAA by high K(+) are complex and may involve both swelling and activation of NMDA-receptors.

In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Publishing Authors By Initials

M Tranberg,AK Abbas,M Sandberg,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research

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In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurochemical research

VOLUME: 32

Page Numbers: 1248-55

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 31

MONTH: 03

YEAR: 2007

In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Keywords Mesh Terms:

KEYWORDS: Water-Electrolyte Balance

MESH TERMS: metabolism

Chemical & Substance for Abstract: In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Information

Substance Name: N-acetylaspartate

Registry Number: 997-55-7

Grant and Affiliation Information for In vitro studies on the putative function of N-acetylaspartate as an osmoregulator.

AFFILIATION: Institute of Neuroscience and Physiology, Department of Physiology, Göteborg University, Göteborg, Sweden.

Country: United States

AGENCY: United States NIGMS

GRANT: GM44842

ACRONYM: GM

MEDLINETA: Neurochem Res

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