In vitro skin permeation evaluation: the only realistic option.

In vitro skin permeation evaluation: the only realistic option. Research Abstract Details 

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In vitro skin permeation evaluation: the only realistic option. Abstract Text:

Increasing requirements for cruelty-free risk assessment in the cosmetic industry have led to the development of several alternative experimental evaluation strategies. Quantification of the potential dermal absorption of ingredients of cosmetic and other formulations by determination of human skin permeation rates in vitro is particularly relevant. Using modifications of standard in vitro protocols the human skin permeation rates of several cosmetic ingredients and potential contaminants have been determined under conditions designed to mimic consumer use. Skin penetration and permeation of octyl salicylate (a sunscreen), nonylphenol ethoxylates (surfactants) and three nitrosamines (potential contaminants) is discussed. The data demonstrate the usefulness of this technique as a tool in the overall risk assessment of cosmetic formulations.

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In vitro skin permeation evaluation: the only realistic option. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cosmetic science

VOLUME: 20

Page Numbers: 307-16

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ISSN: 0142-5463

DAY: 28

MONTH: Oct

YEAR: 1998

In vitro skin permeation evaluation: the only realistic option. Information

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LANGUAGE: eng

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Grant and Affiliation Information for In vitro skin permeation evaluation: the only realistic option.

AFFILIATION: An-eX analytical services Ltd, Redwood Building, King Edward VIIAvenue, Cardiff, UK.

Country: England

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MEDLINETA: Int J Cosmet Sci

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