[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil]

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[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil] Abstract Text:

J Han,W Yan,Q Qian,M Han,L Qiu,H Shi,C Li,X Li,J Qi,S Feng,

OBJECTIVE: To investigate the reversal of homoharringtonine (HHT)-resistance by tamoxifen (TAM) or verapamil (VER) alone or in combination. METHODS: The drug-sensitivity test was performed with semisolid agar culture. RESULTS: The cytotoxicity of HHT to K562/S cells was not enhanced by TAM or VER alone or in combination,but HHT resistance in HHT resistant cells (K562/H20) was reversed by VER and TAM at nontoxic doses (4micromol/L or 8micromol/L). The IC50 of K562/H20 for HHT decreased from 446.8 +/- 0.08microg/L to 45.1 +/- 0.02microg/L in the presence of 4micromol/L of VER, to 22.4 +/- 0.03microg/L in 8micromol/L of VER, to 85.1 +/- 0.03microg/L in 4micromol/L of TAM and to 26.4 +/- 0.02microg/L in 8micromol/L of TAM. In the presence of combinations of 2micromol/L VER and 4micromol/L TAM and of 2micromol/L VER and 8micromol/L TAM, IC50 of K562/H20 decreased to 30.4 +/- 0.02microg/L and 4.3 +/- 0.04microg/L, respectively. CONCLUSION: HHT-resistance could be reversed by VER or TAM alone, and the combination of the two drugs showed a synergistic effect.

[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil] Publishing Authors By Initials

J Han,W Yan,Q Qian,M Han,L Qiu,H Shi,C Li,X Li,J Qi,S Feng,

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[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 143-6

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: Mar

YEAR: 1997

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LANGUAGE: chi

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AFFILIATION: Institute of Hematology, Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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