In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres.

In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Research Abstract Details 

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In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Abstract Text:

Eun Ji Park,Dong Hee Na,Kang Choon Lee,

The purpose of this study was to investigate in vitro release property of mono-PEGylated growth hormone-releasing peptide-6 (GHRP-6) microspheres. The microspheres encapsulating native GHRP-6 or mono-PEG-GHRP-6 were prepared using the single oil-in-water emulsion solvent evaporation method. In vitro release study was performed in 0.1M phosphate buffer, pH 7.4, containing 0.02% Tween 80 and sodium azide at 37 or 55 degrees C. The mono-PEG-GHRP-6 microspheres showed a lower initial burst compared with native GHRP-6 microspheres and zero-order release profile for a 1-month period. The release period was dependent on the PEG size attached to the GHRP-6 with more rapid drug release being observed with the smaller PEG size. This study suggests that PEGylated peptide has good potential as a source for a sustained release microsphere delivery system.

In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Publishing Authors By Initials

EJ Park,DH Na,KC Lee,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of pharmaceutics

VOLUME: 343

Page Numbers: 281-3

Journal Abbreviation:

ISSN: 0378-5173

DAY: 14

MONTH: 06

YEAR: 2007

In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Information

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LANGUAGE: eng

NlmUniqueID: 7804127

In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: chemistry

Chemical & Substance for Abstract: In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Information

Substance Name: growth hormone releasing hexapeptide

Registry Number: 87616-84-0

Grant and Affiliation Information for In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres.

AFFILIATION: Drug Targeting Laboratory, College of Pharmacy, SungKyunKwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea.

Country: Netherlands

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MEDLINETA: Int J Pharm

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