In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation.

In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Research Abstract Details 

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In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Abstract Text:

PURPOSE: Our experience with IVF using low-dose clomiphene citrate for stimulation in "non-" and "poor" responders was reviewed and the treatment outcomes with the previous controlled ovarian stimulation cycles in which hMG and GnRH agonist were used were compared. METHODS: The treatment outcome in 11 non- and 20 poor responders having 30 and 53 clomiphene citrate IVF treatment cycles, respectively, were compared with the treatment outcome in the previous long-protocol buserelin/hMG cycles. RESULTS: The clinical pregnancy rates per oocyte collection achieved in the first clomiphene citrate cycle in non (9.1%)- and poor (10%) responders were comparable to those achieved by poor responders (11.9%) who had buserelin/hMG using the long protocol. Although the numbers were small, a similar pregnancy rate could still be achieved in poor responders up to the third attempt using clomiphene citrate. CONCLUSIONS: IVF using long-protocol buserelin/hMG is more successful than using clomiphene citrate stimulation. However, this advantage may not be significant in those women with a previous poor response to buserelin/hMG. It is suggested that for such poor responders, three attempts of IVF in a clomiphene citrate cycle may offer a viable therapeutic alternative before reverting to more stressful, expensive, and time-consuming treatment.

In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Publishing Authors By Initials

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of assisted reproduction and genetics

VOLUME: 14

Page Numbers: 503-7

Journal Abbreviation: J. Assist. Reprod. Genet.

ISSN: 1058-0468

DAY: 17

MONTH: Oct

YEAR: 1997

In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9206495

In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: physiology

Chemical & Substance for Abstract: In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation. Information

Substance Name: Clomiphene

Registry Number: 911-45-5

Grant and Affiliation Information for In vitro fertilization with low-dose clomiphene citrate stimulation in women who respond poorly to superovulation.

AFFILIATION: Midland Fertility Services, Centre House, Aldridge, U.K.

Country: UNITED STATES

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MEDLINETA: J Assist Reprod Genet

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