[In vitro expression of wild type and precore mutant woodchuck hepatitis virus]

[In vitro expression of wild type and precore mutant woodchuck hepatitis virus] Research Abstract Details 

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[In vitro expression of wild type and precore mutant woodchuck hepatitis virus] Abstract Text:

Q Lu,L Zhang,C Liang,K Luo,

Hepatitis B virus (HBV) precore 1896 and 1898 G-->A mutations are regarded as hot spots to study. Such mutants have been considered associating with molecular and biological changes of HBV and causing chronic hepatitis and severe forms of hepatitis, including fulminant hepatitis. Using oligonucleotide-directed mutagenesis, we have conducted the same point mutations in the precore gene of an infectious clone of woodchuck hepatitis virus (WHV-8). Transfection of mutant WHV DNA, 1896 mutant (WHV-M1) or both 1896 and 1898 mutants (WHV-M2) resulted in WHV replication. Southern blot and Northern blot tests showed that wild type and mutants both had similar DNA replication and transcription. It was concluded that the precore gene of the WHV genome is not essential for virus replication.

[In vitro expression of wild type and precore mutant woodchuck hepatitis virus] Publishing Authors By Initials

Q Lu,L Zhang,C Liang,K Luo,

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[In vitro expression of wild type and precore mutant woodchuck hepatitis virus] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi

VOLUME: 11

Page Numbers: 107-9

Journal Abbreviation: Zhonghua Shi Yan He Lin Chuang

ISSN: 1003-9279

DAY: 28

MONTH: Jun

YEAR: 1997

[In vitro expression of wild type and precore mutant woodchuck hepatitis virus] Information

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LANGUAGE: chi

NlmUniqueID: 9602873

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AFFILIATION: Department of Infectious Diseases, Nanfang Hospital, The First Military Medical University, Guangzhou 510515.

Country: China

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MEDLINETA: Zhonghua Shi Yan He Lin Chuang

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