In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.

In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Research Abstract Details 

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In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Abstract Text:

Fabiana Dal Pozzo,Graciela Andrei,Ilya Lebeau,James R Beadle,Karl Y Hostetler,Erik De Clercq,Robert Snoeck,

Acyclic nucleoside phosphonates (ANPs) and in particular (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir, CDV, Vistide) and its adenine counterpart (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA] are highly active against orf virus infections. This parapoxvirus commonly causes infection in sheep, goats, but also humans. Alkoxyalkyl esters of CDV have an increased oral bioavailability and are more active against orthopoxviruses than the parent compounds. In the present study, the potency of several alkoxyalkyl esters of CDV, cyclic cidofovir (cCDV) and (S)-HPMPA was evaluated against different orf virus isolates in two cell types, human embryonic lung (HEL) fibroblast and primary lamb keratinocytes. Each prodrug was at least 10-fold more active than its parent compound in both cell types. Of all the compounds tested, the (S)-HPMPA alkoxyalkyl esters showed the highest activity and selectivity against orf virus. Our results support the development of alkoxyalkyl esters of ANPs as antivirals not only for the treatment of complicated human orf lesions, but also in the therapy and prophylaxis of contagious ecthyma in sheep and goats.

In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Publishing Authors By Initials

F Dal Pozzo,G Andrei,I Lebeau,JR Beadle,KY Hostetler,E De Clercq,R Snoeck,

For similar animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research

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In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Antiviral research

VOLUME: 75

Page Numbers: 52-7

Journal Abbreviation:

ISSN: 0166-3542

DAY: 13

MONTH: 12

YEAR: 2006

In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109699

In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Keywords Mesh Terms:

KEYWORDS: Sheep

MESH TERMS: pharmacology

Chemical & Substance for Abstract: In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Information

Substance Name: 9-(3-hydroxy-2-phosphonylmethoxypropyl)a

Registry Number: 92999-29-6

Grant and Affiliation Information for In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.

AFFILIATION: Rega Institute for Medical Research, K.U.Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI 066499

ACRONYM: AI

MEDLINETA: Antiviral Res

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