In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer.

In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer. Research Abstract Details 

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In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer. Abstract Text:

Tatsuya Yoshimasu,Shoji Oura,Issei Hirai,Takeshi Tamaki,Yozo Kokawa,Fuminori Ota,Rie Nakamura,Yukio Shimizu,Mitsumasa Kawago,Yoshimitsu Hirai,Koma Naito,Megumi Kiyoi,Hirokazu Tanino,Yoshitaka Okamura,Tomoko Furukawa,Tatsuya Yoshimasu,Shoji Oura,Issei Hirai,Takeshi Tamaki,Yozo Kokawa,Fuminori Ota,Rie Nakamura,Yukio Shimizu,Mitsumasa Kawago,Yoshimitsu Hirai,Koma Naito,Megumi Kiyoi,Hirokazu Tanino,Yoshitaka Okamura,Tomoko Furukawa,Tatsuya Yoshimasu,Shoji Oura,Issei Hirai,Takeshi Tamaki,Yozo Kokawa,Fuminori Ota,Rie Nakamura,Yukio Shimizu,Mitsumasa Kawago,Yoshimitsu Hirai,Koma Naito,Megumi Kiyoi,Hirokazu Tanino,Yoshitaka Okamura,Tomoko Furukawa,

Background: The dose-response curve for anticancer agents cannot be evaluated by studying patients directly. To investigate individual differences in the dose-response curve for paclitaxel in breast cancer, we utilized the histoculture drug response assay (HDRA) technique.Materials and Methods: Twenty specimens obtained from breast cancer patients who underwent surgical resection were used in this study. The inhibition rates of paclitaxel at several concentrations were measured and fitted to a sigmoid dose-response curve, using non-linear least squares analysis with the fitting equation y=A(1-1/(1+exp(B(x-log(C))))), where A denotes maximal response; B, slope factor; and C, ED50.Results: A dose-response curve was obtained in all tumors. The mean value (+/-SD) of maximum response, slope factor, and ED50 were 90.2+/-5.5%, 9.4+/-4.3, and 36.8+/-17.2microg/ml, respectively. The slope factor was higher in nuclear grade 3 tumors compared with nuclear grade 1 and 2 tumors.Conclusion: An individual dose-response curve for paclitaxel in breast cancer can be obtained using the HDRA technique. Nuclear grade 3 tumors appeared to have more uniform chemosensitivity to paclitaxel compared with nuclear grade 1 and 2 tumors.

In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer. Publishing Authors By Initials

T Yoshimasu,S Oura,I Hirai,T Tamaki,Y Kokawa,F Ota,R Nakamura,Y Shimizu,M Kawago,Y Hirai,K Naito,M Kiyoi,H Tanino,Y Okamura,T Furukawa,T Yoshimasu,S Oura,I Hirai,T Tamaki,Y Kokawa,F Ota,R Nakamura,Y Shimizu,M Kawago,Y Hirai,K Naito,M Kiyoi,H Tanino,Y Okamura,T Furukawa,T Yoshimasu,S Oura,I Hirai,T Tamaki,Y Kokawa,F Ota,R Nakamura,Y Shimizu,M Kawago,Y Hirai,K Naito,M Kiyoi,H Tanino,Y Okamura,T Furukawa,

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In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Breast cancer (Tokyo, Japan)

VOLUME: 14

Page Numbers: 401-5

Journal Abbreviation: Breast Cancer

ISSN: 1340-6868

DAY: 7

MONTH: 11

YEAR: 2007

In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer. Information

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LANGUAGE: eng

NlmUniqueID: 100888201

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Grant and Affiliation Information for In vitro Evaluation of Dose-Response Curve for Paclitaxel in Breast Cancer.

AFFILIATION: Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University.

Country: Japan

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MEDLINETA: Breast Cancer

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