In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage.

In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Research Abstract Details 

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In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Abstract Text:

T Libondi,M Menzione,G Auricchio,

Lysophosphatidylcholine (LPC) has been shown to be toxic to the lens in organ culture. An investigation into whether vitamin E counteracts the in vitro damaging effect of LPC on rat lenses was undertaken. A concentration higher than 10 micrograms ml-1 LPC in the culture medium is necessary to damage rat lenses, as assessed by protein content of the medium and Na+ and K+ content of the lens. Vitamin E affords its protection when present at a concentration of 10(-3) M: both the protein efflux from the lens and the lenticular cation imbalance are prevented, also if LPC concentration is 100 micrograms ml-1. This effect may be due more to the physicochemical properties of vitamin E in the stabilization of biological membranes, than to its chemical behaviour as an antioxidant.

In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Publishing Authors By Initials

T Libondi,M Menzione,G Auricchio,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental eye research

VOLUME: 40

Page Numbers: 661-6

Journal Abbreviation: Exp. Eye Res.

ISSN: 0014-4835

DAY: 19

MONTH: May

YEAR: 1985

In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370707

In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage.

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Country: ENGLAND

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MEDLINETA: Exp Eye Res

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