In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer.

In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer. Research Abstract Details 

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In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer. Abstract Text:

Edward J Boland,David L Carnes,Mary MacDougall,Neera Satsangi,Ralph Rawls,Barry Norling,

The objective of this study was to determine the in vitro cytotoxicity of novel, polymerizable liquid crystal resin monomers when placed in direct contact with dental and nondental cell lines. One common dimethacrylate and three liquid crystal compounds, Bis-glycidyl methacrylate (Bis-GMA), 2-(t-butyl)-1,4-bis-{4-(6-acryloxy-hexane-1-oxy)-benzoyloxy}-benzene (C6), 2-(t-butyl), 1-[6-(3-acryloxy-propionoxy)-hexane-1-oxy-benzoyloxy], 4-[4-(6-acryloxy-hexane-1-oxy)-benzoyloxy]-benxene (by-product), and a 3:2 mixture of C6 and by-product, respectively, were tested for relative cytotoxicity in vitro. Cultured dental and nondental cells were treated for 24 h with test compound dissolved in media over a fourfold range of concentration (10(-4) -10(-7) mol/L). Cytotoxicity was measured using the WST-1 reagent as an indicator of remaining cell numbers based on the reduction of WST-1 substrate by mitochondrial dehydrogenases in viable cells. Bis-GMA ID(50) was found to be consistent with ID(50) values reported in the literature. A small but significant difference in the sensitivity of the dental and nondental cells in regard to their response to this dimethacrylate was noted. The liquid crystal resin monomers were significantly less cytotoxic to all cell lines tested. ID(50) values of >1 x 10(-4) mol/L were registered for the C6 and by-product monomers alone. The 3:2 mixture of C6 and by-product had a slightly higher cytotoxicity (ID(50) = 1 x 10(-4) mol/L); however, this remained significantly less than that of Bis-GMA. The results demonstrate that the newly synthesized low-shrinkage, polymerizable liquid crystal resin monomers demonstrate a minimal cytotoxic effect on both dental and nondental cells. These data suggest that the low-shrinkage liquid crystal resin monomers will not elicit a response by oral tissues (pulp tissue) when used to repair carious lesions in posterior teeth.

In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer. Publishing Authors By Initials

EJ Boland,DL Carnes,M MacDougall,N Satsangi,R Rawls,B Norling,

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In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biomedical materials research. Part B,

VOLUME: 79

Page Numbers: 1-6

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ISSN: 1552-4973

DAY: 3

MONTH: Oct

YEAR: 2006

In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer. Information

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LANGUAGE: eng

NlmUniqueID: 101234238

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Grant and Affiliation Information for In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer.

AFFILIATION: Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. boland@uthscsa.edu

Country: United States

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MEDLINETA: J Biomed Mater Res B Appl Biom

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