In vitro activity of terpenes against Candida biofilms.

In vitro activity of terpenes against Candida biofilms. Research Abstract Details 

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In vitro activity of terpenes against Candida biofilms. Abstract Text:

The antibiofilm activity of 10 terpenes was tested in vitro against three Candida species by 24-h treatment of biofilms aged 1-5 days. Treatment of 24-h-old Candida albicans biofilms with carvacrol, geraniol or thymol (0.06%) resulted in >80% inhibition. Carvacrol (0.03%) inhibition was >/=75% independent of the age of the C. albicans biofilm. Carvacrol (0.125%) inhibition was >75% against Candida glabrata and Candida parapsilosis biofilms. Geraniol (>/=0.125%) and thymol (0.06% or 0.125%) inhibition was >75% against C. parapsilosis biofilms whatever their age. This study demonstrates the antibiofilm activity of terpenes and points out the exceptional efficiency of carvacrol, geraniol and thymol, which could represent candidates in the treatment of candidiasis associated with medical devices.

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In vitro activity of terpenes against Candida biofilms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of antimicrobial agents

VOLUME: 31

Page Numbers: 572-6

Journal Abbreviation: Int. J. Antimicrob. Agents

ISSN: 0924-8579

DAY: 28

MONTH: 04

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9111860

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AFFILIATION: UMR 6008, Université de Poitiers, CNRS, 6 rue de la Milètrie, BP 199, 86034 Poitiers Cedex, France; FRE 3091, Université de Poitiers, CNRS, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France.

Country: Netherlands

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MEDLINETA: Int J Antimicrob Agents

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