In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum.

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Research Abstract Details 

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In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Abstract Text:

Alexa C Rosypal,James E Hall,Svetlana Bakunova,Donald A Patrick,Stanislav Bakunov,Chad E Stephens,Arvind Kumar,David W Boykin,Richard R Tidwell,

Canine leishmaniasis caused by Leishmania infantum is enzootic in the North American foxhound population. Currently available chemotherapy for canine leishmaniasis is not completely effective and relapses are common in treated dogs. Pentamidine and related aromatic diamidines possess broad spectrum antiprotozoal activity. The in vitro antileishmanial activities of 35 aromatic cationic molecules were determined, using pentamidine as the reference drug. The compounds were examined for activity against promastigotes of L. infantum isolated from a foxhound from Virginia. The compounds most active against Leishmania parasites were reversed amidines. Compound 9, a reversed amidine, exhibited the highest activity against L. infantum, with a 50% inhibitory concentration (IC(50)) of 0.0042 microM compared with 14.2 microM for pentamidine. Antileishmanial activities of nine compounds were at least 1000-fold higher relative to the reference drug. Results from this study indicate that several pentamidine-related compounds warrant further investigation as possible new agents for the treatment of canine leishmaniasis.

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Publishing Authors By Initials

AC Rosypal,JE Hall,S Bakunova,DA Patrick,S Bakunov,CE Stephens,A Kumar,DW Boykin,RR Tidwell,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Veterinary parasitology

VOLUME: 145

Page Numbers: 207-16

Journal Abbreviation: Vet. Parasitol.

ISSN: 0304-4017

DAY: 12

MONTH: 02

YEAR: 2007

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Information

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LANGUAGE: eng

NlmUniqueID: 7602745

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: veterinary

Chemical & Substance for Abstract: In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Information

Substance Name: Antiprotozoal Agents

Registry Number: 0

Grant and Affiliation Information for In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum.

AFFILIATION: School of Medicine, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. arosypal@email.unc.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM 00678

ACRONYM: GM

MEDLINETA: Vet Parasitol

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