In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci.

In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci. Research Abstract Details 

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In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci. Abstract Text:

Catherine Clark,Kathy Smith,Lois Ednie,Tatiana Bogdanovich,Bonifacio Dewasse,Pamela McGhee,Peter C Appelbaum,

DC-159a yielded MICs of /=4 mug/ml). Although the MICs for DC-159a against quinolone-susceptible pneumococci were a few dilutions higher than those of gemifloxacin, the MICs of these two compounds against 28 quinolone-resistant pneumococci were identical. The DC-159a MICs against quinolone-resistant strains did not appear to depend on the number or the type of mutations in the quinolone resistance-determining region. DC-159a, as well as the other quinolones tested, was bactericidal after 24 h at 2x MIC against 11 of 12 strains tested. Two of the strains were additionally tested at 1 and 2 h, and DC-159a at 4x MIC showed significant killing as early as 2 h. Multistep resistance selection studies showed that even after 50 consecutive subcultures of 10 strains in the presence of sub-MICs, DC-159a produced only two mutants with maximum MICs of 1 mug/ml.

In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci. Publishing Authors By Initials

C Clark,K Smith,L Ednie,T Bogdanovich,B Dewasse,P McGhee,PC Appelbaum,

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In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Antimicrobial agents and chemotherapy

VOLUME: 52

Page Numbers: 77-84

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 15

MONTH: 10

YEAR: 2007

In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci. Information

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LANGUAGE: eng

NlmUniqueID: 315061

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AFFILIATION: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. pappelbaum@psu.edu.

Country: United States

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MEDLINETA: Antimicrob Agents Chemother

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