In vitro activating properties of polyene antibiotics for murine lymphocytes.

In vitro activating properties of polyene antibiotics for murine lymphocytes. Research Abstract Details 

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In vitro activating properties of polyene antibiotics for murine lymphocytes. Abstract Text:

The effect of four polyene antibiotics, Candicidin, Etruscomycin, Filipin and Pimaricin upon mouse lymphocytes was studied. Polyene antibiotics are known to form aqueous pores in the cell membranes inducing known anion or cation selective fluxes. Candicidin was capable of inducing marked DNA-synthesis and polyclonal antibody production when added to normal spleen cells. Etruscomycin and Pimaricin showed a weak inconsistent DNA synthetic stimulatory effect, whereas Filipin was found to be totally uneffective. The stimulating property of Candicidin was also demonstrated on spleen cells from nude mice whereas there was no effect on cortisone resistant thymocytes or spleen cells passed through a nylon fibre column. Thus we conclude that Candicidin is a PBA for mouse lymphocytes. We have previously reported that the two anionselective polyenes, Nystatin and Amphotericin B, are polyclonal B-cell activators for mouse lymphocytes and in this paper the possible mechanism of triggering is further discussed.

In vitro activating properties of polyene antibiotics for murine lymphocytes. Publishing Authors By Initials

For similar organic chemicals: lactones: macrolides: natamycin research abstracts see: organic chemicals: lactones: macrolides: natamycin research

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In vitro activating properties of polyene antibiotics for murine lymphocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 85C

Page Numbers: 277-83

Journal Abbreviation:

ISSN: 0304-1328

DAY: 26

MONTH: Aug

YEAR: 1977

In vitro activating properties of polyene antibiotics for murine lymphocytes. Information

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LANGUAGE: eng

NlmUniqueID: 7508469

In vitro activating properties of polyene antibiotics for murine lymphocytes. Keywords Mesh Terms:

KEYWORDS: Natamycin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: In vitro activating properties of polyene antibiotics for murine lymphocytes. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for In vitro activating properties of polyene antibiotics for murine lymphocytes.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [C

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