In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells.

In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells. Research Abstract Details 

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In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells. Abstract Text:

Wan Beom Park,Sung Han Kim,Cheol-in Kang,Jae Hyun Cho,Ji Whan Bang,Kyoung Wha Park,Yeong Seon Lee,Nam Joong Kim,Myoung-don Oh,Hong Bin Kim,Kang Won Choe,Wan Beom Park,Sung Han Kim,Cheol-in Kang,Jae Hyun Cho,Ji Whan Bang,Kyoung Wha Park,Yeong Seon Lee,Nam Joong Kim,Myoung-don Oh,Hong Bin Kim,Kang Won Choe,

Invasion of vascular endothelial cells is thought to be a critical step in the development of metastatic infections in patients with Staphylococcus aureus bacteraemia. This study was designed to evaluate the association between the ability to invade endothelial cells and metastatic infection by S. aureus. Patients with metastatic infection were identified among those with community-acquired S. aureus bacteraemia in a tertiary referral hospital. Patients with simple bacteraemia caused by S. aureus over the same period served as the control group. The ability of each clinical isolate to invade endothelial cells was evaluated by counting the number of intracellular organisms 1 h after inoculation onto human umbilical vein endothelial cells in vitro. The cytotoxic activity of intracellular S. aureus was determined 24 h after internalization, and expressed as the percentage of cells killed. The clinical isolates varied in invasiveness and cytotoxicity. The median invasiveness, relative to S. aureus reference strain ATCC 29213, was 145 % in the cases (n=10) [interquartile range (IQR) 103-160] and 153 % (IQR 111-173) in the controls (n=11; P=0.44). The median cytotoxicity was 59.4 % (IQR 47-68) in the cases and 65.2 % (IQR 50-74) in the controls (P=0.44). Differences in the ability of S. aureus to invade and destroy vascular endothelial cells in vitro were not associated with the development of metastatic complications in patients with S. aureus bacteraemia. This implies that the invasiveness and toxicity of S. aureus for endothelial cells may not be major determinants of metastatic infection.

In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells. Publishing Authors By Initials

WB Park,SH Kim,CI Kang,JH Cho,JW Bang,KW Park,YS Lee,NJ Kim,MD Oh,HB Kim,KW Choe,WB Park,SH Kim,CI Kang,JH Cho,JW Bang,KW Park,YS Lee,NJ Kim,MD Oh,HB Kim,KW Choe,

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In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medical microbiology

VOLUME: 56

Page Numbers: 1290-5

Journal Abbreviation: J. Med. Microbiol.

ISSN: 0022-2615

DAY: 25

MONTH: Oct

YEAR: 2007

In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 224131

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Grant and Affiliation Information for In vitro ability of Staphylococcus aureus isolates from bacteraemic patients with and without metastatic complications to invade vascular endothelial cells.

AFFILIATION: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.

Country: England

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MEDLINETA: J Med Microbiol

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