In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Research Abstract Details 

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In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Abstract Text:

Matthew P Longnecker,Beth C Gladen,Lea A Cupul-Uicab,S Patricia Romano-Riquer,Jean-Phillipe Weber,Robert E Chapin,Mauricio ,

The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital distance serves as a measure of fetal androgen action. The authors designed the present study to examine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males. A cross-sectional study of 781 newly delivered male infants was conducted in 2002-2003 in Chiapas, México, where DDT had recently been used for malaria control. Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother's blood was drawn. In this population, the range of serum DDE levels was large (0.8-398 microg/liter). The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth. If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes.

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Publishing Authors By Initials

MP Longnecker,BC Gladen,LA Cupul-Uicab,SP Romano-Riquer,JP Weber,RE Chapin,M ,

For similar male urogenital diseases: urogenital abnormalities research abstracts see: male urogenital diseases: urogenital abnormalities research

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In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: American journal of epidemiology

VOLUME: 165

Page Numbers: 1015-22

Journal Abbreviation:

ISSN: 0002-9262

DAY: 31

MONTH: 01

YEAR: 2007

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7910653

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Keywords Mesh Terms:

KEYWORDS: Urogenital Abnormalities

MESH TERMS: epidemiology

Chemical & Substance for Abstract: In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Information

Substance Name: Dichlorodiphenyl Dichloroethylene

Registry Number: 72-55-9

Grant and Affiliation Information for In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.

AFFILIATION: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. longnec1@niehs.nih.gov

Country: United States

AGENCY: United States NIEHS

GRANT: Z01 ES044009-05

ACRONYM: ES

MEDLINETA: Am J Epidemiol

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