In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Abstract Text:

Tobias Stoeger,Gabriele E Proetzel,Heike Welzel,Apollon Papadimitriou,Carola Dony,Rudi Balling,Clementine Hofmann,

We examined the molecular progression of ectopic bone development upon application of recombinant human bone morphogenetic protein-2 (rhBMP2), using a commercial collagen type I carrier, in the hind quarter muscles of mice. We performed a gene expression study using mRNA in situ hybridisation to compare embryonic cartilage and bone formation with BMP2-induced ectopic bone formation. As bone growth can be induced postnatally or in adult animals, we examined the expression of molecules regulating embryonic bone development. We found that the mRNAs of the same molecules, such as Indian hedgehog (IHH), parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) and BMPs, that regulate embryonic cartilage and bone development, are expressed during BMP-induced ectopic bone formation, suggesting parallels in the mechanisms controlling these processes. Our studies support by molecular means the previous findings in rats that BMP2-induced ectopic bone formation in mice undergoes bone development involving both modes, endochondral and intramembranous ossification, simultaneously at different sites of the implant.

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Publishing Authors By Initials

T Stoeger,GE Proetzel,H Welzel,A Papadimitriou,C Dony,R Balling,C Hofmann,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Growth factors (Chur, Switzerland)

VOLUME: 20

Page Numbers: 197-210

Journal Abbreviation: Growth Factors

ISSN: 0897-7194

DAY: 19

MONTH: Dec

YEAR: 2002

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9000468

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: genetics

Chemical & Substance for Abstract: In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.

AFFILIATION: GSF Research Center Institute of Mammalian Genetics, Ingolstädter Landrtr. 1, D-85764 Neuherberg, Germany.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Growth Factors

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification Related Publications

• Acceptability and suppression of negative emotion in anxiety and mood disorders.
• Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships.
• Combined medical-psychiatric inpatient units: evaluation of the Centre for the Elderly.
• Density functional theory studies of model complexes for molybdenum-dependent nitrate reductase active sites.
• Detrimental and protective bystander effects: a model approach.
• Effects of suppression and acceptance on emotional responses of individuals with anxiety and mood disorders.
• Enhancing exposure-based therapy from a translational research perspective.
• Environmental complexity and social organization sculpt the brain in Lake Tanganyikan cichlid fish.
• Ethical questions at the end of life. When care is more important than treatment.
• Exposure assessment of diesel bus emissions.
• From scinti-mammography and metabolic imaging to receptor targeted PET-new principles of breast cancer detection.
• Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping.
• H2O2 activation of HSP25/27 protects desmin from calpain proteolysis in rat ventricular myocytes.
• Human cecal bile acids: concentration and spectrum.
• Identification of bitter off-taste compounds in the stored cold pressed linseed oil.
• In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.
• Investigations on a novel silyl transfer reaction in heterodimetallic chemistry.
• Is cold the new hot? Elevated ubiquitin-conjugated protein levels in tissues of Antarctic fish as evidence for cold-denaturation of proteins in vivo.
• Masculinized dominant females in a cooperatively breeding species.
• Molecular modeling of prohibitin domains.
• Nonenzymatic C-glycosylation of flavan-3-ols by oligo- and polysaccharides.
• Pre- and perioperative predictors of short-term clinical outcomes in patients undergoing percutaneous nephrolitholapaxy.
• Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation.
• Role of image-guided vascular intervention in therapeutic angiogenesis translational research.
• Somatostatin and somatostatin receptor gene expression in dominant and subordinate males of an African cichlid fish.
• Somatostatin regulates aggressive behavior in an African cichlid fish.
• Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning.
• The area composita of adhering junctions connecting heart muscle cells of vertebrates - III: assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture.
• When ambiguity hurts: social standards moderate self-appraisals in generalized social phobia.
• [In Process Citation]