In silico study of whey-acidic-protein domain containing oral protease inhibitors.

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Abstract Text:

Yoshiko Idoji,Yuko Watanabe,Akifumi Yamashita,Kyosuke Yamanishi,Seiji Nishiguchi,Kazunori Shimada,Teruo Yasunaga,Hiromichi Yamanishi,

Since whey-acidic-protein domain (WAP) containing protease inhibitors such as SLPI (secretory leukocyte protease inhibitor) and elafin (elastase-specific inhibitor) have antimicrobial activities and are thought to play critical roles in mucosal defenses, we are interested in these protease inhibitors. By accessing the Novartis mouse expression database, we found that the four WAP family members, SLPI, WFDC2, WFDC5, and WFDC12, are highly expressed in the oral organs, such as the trachea, tongue, and salivary glands. Since their WAP domains play pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value, we collected 98 WAP homologues and tried to predict their physiological functions by analyzing their amino acid sequence structures. From the multiple alignments of amino acid sequences, we predicted that most of the mammalian N-terminal WAP domains derived from SLPIs and the WAP domains derived from WFDC12s have antimicrobial activities, whereas most of the mammalian C-terminal WAP domains derived from SLPIs and the WAP domains derived from elafins have antiprotease activities. From the phylogenetic tree, it was revealed that an ancestral WAP protein initially diverged into the WFDC5-C WAP domain and the ancestral protein for the other WAP domains. Subsequently, the ancestral protein for the other WAP domains diverged into two ancestral proteins, one for elafin and SLPI-C WAP domains and the other, for SLPI-N, WFDC15b, WFDC12, and WFDC5-N WAP domains, respectively. Moreover, the tree indicated that the WFDC5-N and WFDC12 WAP domains share a common ancestral protein.

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Publishing Authors By Initials

Y Idoji,Y Watanabe,A Yamashita,K Yamanishi,S Nishiguchi,K Shimada,T Yasunaga,H Yamanishi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of molecular medicine

VOLUME: 21

Page Numbers: 461-8

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 24

MONTH: Apr

YEAR: 2008

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9810955

In silico study of whey-acidic-protein domain containing oral protease inhibitors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: In silico study of whey-acidic-protein domain containing oral protease inhibitors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for In silico study of whey-acidic-protein domain containing oral protease inhibitors.

AFFILIATION: Hirakata Ryoikuen, Tsudahigashi 2-1-1, Hirakata, Osaka 573-0122, Japan.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Mol Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

In silico study of whey-acidic-protein domain containing oral protease inhibitors Related Publications

• A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb.
• A simple and effective technique for the cryotherapy of digital mucous cysts.
• Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts.
• Detection of human alpha-herpesvirus DNA using consensus primers and specific probes.
• Development of varicella vaccine.
• Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes.
• Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway.
• Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity.
• In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes.
• In silico study of whey-acidic-protein domain containing oral protease inhibitors.
• Induction of neutralizing antibody against varicella-zoster virus (VZV) by VZV gp3 and cross-reactivity between VZV gp3 and herpes simplex viruses gB.
• Ingested beta-carotene enhances glutathione level and up-regulates the activity of cysteine cathepsin in murine splenocytes.
• KEGG for linking genomes to life and the environment.
• Molecular analysis of the Oka vaccine strain of varicella-zoster virus.
• Staphylococcal enterotoxin B enhances a flare-up reaction of murine contact hypersensitivity through up-regulation of interferon-gamma.
• Wideband deep penetration of photon-number fluctuations into the quantum regime in series-coupled light-emitting diodes.
• [Effects of resistance training on physical fitness, muscle strength, and natural killer cell activity in female university students]