In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes.

In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. Research Abstract Details 

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In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. Abstract Text:

We found that a cDNA clone isolated from a mouse testis cDNA library, 1700015G11 (Mmu_15G11), corresponded to the most highly expressed testis-specific mRNA in the adult mouse. Although the Mmu_15G11 cDNA is predicted to encode a small protein consisting of 67 amino acid residues, it has not yet been functionally annotated and has been designated as an unclassifiable clone. Since the Mmu_15G11 protein possibly has a pivotal role in spermatogenesis, we initiated an in silico study of this clone, and revealed that an ancestral gene of 15G11 genes evolved from an ancestral gene for mammalian small valosin-containing protein-interacting protein (SVIP) genes by gene duplication. Although SVIP protein reportedly participates in endoplasmic reticulum-related protein degradation, 15G11 protein is predicted to be a nuclear protein and possibly participates in the interaction between proteins and nuclear DNA.

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In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of molecular medicine

VOLUME: 22

Page Numbers: 143-8

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 18

MONTH: Aug

YEAR: 2008

In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. Information

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LANGUAGE: eng

NlmUniqueID: 9810955

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Grant and Affiliation Information for In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes.

AFFILIATION: Hirakata Ryoikuen, 2-1-1 Tsudahigashi, Hirakata, Osaka 573-0122, Japan.

Country: Greece

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MEDLINETA: Int J Mol Med

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