In-silico fragment-based identification of novel angiogenesis inhibitors.

In-silico fragment-based identification of novel angiogenesis inhibitors. Research Abstract Details 

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In-silico fragment-based identification of novel angiogenesis inhibitors. Abstract Text:

Sivanesan Dakshanamurthy,Min Kim,Milton L Brown,Stephen W Byers,

Inhibition of vascular endothelial growth factor receptor-2 (VEGFR2) kinase blocks angiogenesis, the process of generating new capillary blood vessels that are important in tumor growth. To identify small molecule inhibitors of the VEGFR2 kinase, we undertook a computer assisted fragment-based screening that used 3-D structural models of the VEGFR2 kinase, and hinge region as a fragment anchor point. Seven novel non-cytotoxic compounds were identified which limited the induction of capillary networks by human umbilical vein endothelial cells in the low micromolar range.

In-silico fragment-based identification of novel angiogenesis inhibitors. Publishing Authors By Initials

S Dakshanamurthy,M Kim,ML Brown,SW Byers,

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In-silico fragment-based identification of novel angiogenesis inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4551-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 15

MONTH: 06

YEAR: 2007

In-silico fragment-based identification of novel angiogenesis inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

In-silico fragment-based identification of novel angiogenesis inhibitors. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor Recep

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: In-silico fragment-based identification of novel angiogenesis inhibitors. Information

Substance Name: Vascular Endothelial Growth Factor Recep

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for In-silico fragment-based identification of novel angiogenesis inhibitors.

AFFILIATION: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA. sd233@georgetown.edu

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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