In search of polymorphic Alu insertions with restricted geographic distributions.

In search of polymorphic Alu insertions with restricted geographic distributions. Research Abstract Details 

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In search of polymorphic Alu insertions with restricted geographic distributions. Abstract Text:

Richard Cordaux,Deepa Srikanta,Jungnam Lee,Mark Stoneking,Mark A Batzer,

Alu elements are transposable elements that have reached over one million copies in the human genome. Some Alu elements inserted in the genome so recently that they are still polymorphic for insertion presence or absence in human populations. Recently, there has been an increasing interest in using Alu variation for studies of human population genetic structure and inference of individual geographic origin. Currently, this requires a high number of Alu loci. Here, we used a linker-mediated polymerase chain reaction method to preferentially identify low-frequency Alu elements in various human DNA samples with different geographic origins. The candidate Alu loci were subsequently genotyped in 18 worldwide human populations (approximately 370 individuals), resulting in the identification of two new Alu insertions restricted to populations of African ancestry. Our results suggest that it may ultimately become possible to correctly infer the geographic affiliation of unknown samples with high levels of confidence without having to genotype as many as 100 Alu loci. This is desirable if Alu insertion polymorphisms are to be used for human evolution studies or forensic applications.

In search of polymorphic Alu insertions with restricted geographic distributions. Publishing Authors By Initials

R Cordaux,D Srikanta,J Lee,M Stoneking,MA Batzer,

For similar genetic phenomena: variation (genetics): polymorphism, genetic research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic research

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In search of polymorphic Alu insertions with restricted geographic distributions. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Genomics

VOLUME: 90

Page Numbers: 154-8

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 11

MONTH: 05

YEAR: 2007

In search of polymorphic Alu insertions with restricted geographic distributions. Information

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LANGUAGE: eng

NlmUniqueID: 8800135

In search of polymorphic Alu insertions with restricted geographic distributions. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: genetics

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Grant and Affiliation Information for In search of polymorphic Alu insertions with restricted geographic distributions.

AFFILIATION: Department of Biological Sciences, Biological Computation and Visualization Center, Center for BioModular Multi-Scale Systems, Louisiana State University, Baton Rouge, LA 70803, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM59290

ACRONYM: GM

MEDLINETA: Genomics

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