In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications.

In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Research Abstract Details 

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In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Abstract Text:

Tao Pan,Gina S Fiorini,Daniel T Chiu,Adam T Woolley,

A new technique for polymer microchannel surface modification, called in-channel atom-transfer radical polymerization, has been developed and applied in the surface derivatization of thermoset polyester (TPE) microdevices with poly(ethylene glycol) (PEG). X-ray photoelectron spectroscopy, electroosmotic flow (EOF), and contact angle measurements indicate that PEG has been grafted on the TPE surface. Moreover, PEG-modified microchannels have much lower and more pH-stable EOF, more hydrophilic surfaces and reduced nonspecific protein adsorption. Capillary electrophoresis separation of amino acid and peptide mixtures in these PEG-modified TPE microchips had good reproducibility. Phosducin-like protein and phosphorylated phosducin-like protein were also separated to measure the phosphorylation efficiency. Our results indicate that PEG-grafted TPE microchips have broad potential application in biomolecular analysis.

In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Publishing Authors By Initials

T Pan,GS Fiorini,DT Chiu,AT Woolley,

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In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Electrophoresis

VOLUME: 28

Page Numbers: 2904-11

Journal Abbreviation: Electrophoresis

ISSN: 0173-0835

DAY: 3

MONTH: Aug

YEAR: 2007

In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8204476

In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications. Information

Substance Name: Fluorescein-5-isothiocyanate

Registry Number: 3326-32-7

Grant and Affiliation Information for In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications.

AFFILIATION: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA.

Country: Germany

AGENCY: United States NIGMS

GRANT: GM065293

ACRONYM: GM

MEDLINETA: Electrophoresis

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