Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake.

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Research Abstract Details 

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Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Abstract Text:

Jennifer L Perry,Sarah E Nelson,Marissa M Anderson,Andrew D Morgan,Marilyn E Carroll,

Previous research in rats indicates that delay discounting for food, a model of impulsivity, predicted the rate of acquisition of cocaine self-administration. In other studies, rats bred for high saccharin intake (HiS) acquired cocaine self-administration at higher rates than those with low saccharin intake (LoS), and female (F) rats acquired cocaine self-administration more rapidly than males (M). The purpose of this study was to examine a possible connection between impulsivity, saccharin intake, and sex by comparing M and F rats from the HiS and LoS selectively bred lines on measures of impulsivity; i.e., their rate of delay discounting for food or i.v. cocaine infusions. The adjusting delay procedure allowed rats access to 2 response levers, and a pellet dispenser or an i.v. drug infusion pump. In 4 groups (HiS M, HiS F, LoS M, LoS F) responses under a fixed-ratio (FR) 1 schedule on one lever resulted in one 45 mg pellet immediately, and responses on the other lever resulted in 3 or 6 pellets after a delay. Four additional groups received either a small cocaine (0.2, 0.4, or 0.8 mg/kg) infusion immediately or a delayed larger infusion (3x the amount of the small infusions). The delay to the larger reinforcer began at 6 s and increased or decreased by 1 s following responses on the delay or immediate levers, respectively. A mean adjusted delay (MAD) was calculated over 30 choice trials during each daily 3-hour session, and it was used as a quantitative measure of impulsivity. In groups maintained by food, HiS rats were more impulsive (lower MADs) than LoS rats, and LoS females were more impulsive than LoS males. There were no phenotype or sex differences in delay discounting for cocaine. Understanding the relationship between impulsivity and other predictors of drug abuse (e.g., sex, saccharin intake) is important in developing prevention and treatment strategies.

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Publishing Authors By Initials

JL Perry,SE Nelson,MM Anderson,AD Morgan,ME Carroll,

For similar reproductive and urinary physiology: reproduction: sex characteristics research abstracts see: reproductive and urinary physiology: reproduction: sex characteristics research

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Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 86

Page Numbers: 822-37

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 3

MONTH: 04

YEAR: 2007

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 367050

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Keywords Mesh Terms:

KEYWORDS: Sex Characteristics

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Information

Substance Name: Saccharin

Registry Number: 81-07-2

Grant and Affiliation Information for Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake.

AFFILIATION: Department of Psychology, University of Kentucky, Lexington, KY 40536-0509, USA. Jennifer.Perry@uky.edu

Country: United States

AGENCY: United States NIDA

GRANT: R01 DA03240-22

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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