Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets.

Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Research Abstract Details 

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Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Abstract Text:

Rakesh Kumar,Neena Lal,Abass Alavi,

MRI is a sensitive method for detecting invasive breast cancer, but it lacks specificity. To examine the effect of combining PET with MRI on breast lesion characterization, a prototype positioning device was fabricated to allow PET scans to be acquired in the same position as MRI scans--that is, prone. METHODS: To test the hypothesis that fusion of (18)F-FDG PET and MRI scans improves detection of breast cancer, 23 patients with suspected recurrent or new breast cancer underwent a routine whole-body PET scan, a prone PET scan of the chest, and a routine breast MRI scan. The attenuation-corrected prone PET and MRI datasets were registered twice by different operators. The fusion results were judged for quality by visual inspection and statistical analysis. A joint reading of the MRI and PET scans side by side and integrated images was performed by a nuclear medicine physician and a radiologist. Sensitivity and specificity of MRI and combined MRI and PET scans were calculated on the basis of pathology reports or at least 1 y of clinical and radiologic follow-up. RESULTS: All fusions were verified to be well matched using specific anatomic criteria. A total of 45 lesions was assessed. Lesion size range was 0.6 to 10.0 cm. Of the 44 breasts examined, 29 were suspicious for cancer, of which 15 were found to be positive on surgical excision. In lesion-by-lesion analysis, sensitivity and specificity of MRI alone were 92% and 52%, respectively; after MRI and PET fusion, they were 63% and 95%, respectively. The positive predictive value and the negative predictive value for MRI alone were 69% and 85%, respectively; after MRI and PET fusion, they were 94% and 69%, respectively. CONCLUSION: Acquisition of prone PET scans using the new positioning device permitted acquisition of prone scans suitable for fusion with breast MRI scans. Fused PET and MRI scans increased the specificity of MRI but decreased the sensitivity in this small group of patients. Additional data are needed to confirm the statistical significance of these preliminary findings.

Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Publishing Authors By Initials

R Kumar,N Lal,A Alavi,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 528-37

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 26

MONTH: Apr

YEAR: 2007

Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: methods

Chemical & Substance for Abstract: Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets. Information

Substance Name: Fluorodeoxyglucose F18

Registry Number: 63503-12-8

Grant and Affiliation Information for Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets.

AFFILIATION: Department of Radiology, School of Medicine, New York University, New York, New York 10016, USA.

Country: United States

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MEDLINETA: J Nucl Med

REFSOURCE: J Nucl Med. 2007 Oct;48(10):1751; author

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