Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion.

Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Research Abstract Details 

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Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Abstract Text:

Qin Gao,Hong-Yang Pan,Qiang Xia,Iain Bruce,

The aim of the present study was to determine whether the clinically effective cardioprotection conferred by puerarin (Pue) against ischemia and reperfusion is mediated by mitochondrial transmembrane pores and/or channels. In isolated rat hearts subjected to 30 min regional ischemia and 120 min reperfusion, pretreatment with Pue at 0.24 mmol/L for 5 min before ischemia increased myocardial formazan content, an index of myocardial viability, reduced lactate dehydrogenase release, improved recovery of the maximal rise/fall rate of left ventricular pressure, left ventricular end-diastolic pressure and rate-pressure product (left ventricular developed pressure multiplied by heart rate) during reperfusion. Administration of atractyloside (20 micromol/L), an opener of the mitochondrial permeability transition pore, for the first 20 min of reperfusion and 5-hydroxydecanoate (100 micromol/L), the mitochondrial specific ATP-sensitive potassium channel blocker, for 20 min before ischemia, attenuated the protective effects of Pue. In mitochondria isolated from hearts pretreated with 0.24 mmol/L Pue for 5 min, a significant inhibition of Ca²⁺-induced swelling was observed, and this inhibition was attenuated by 5-hydroxydecanoate. These findings indicate that Pue protects the myocardium against ischemia and reperfusion injury via inhibiting mitochondrial permeability transition pore opening and activating the mitochondrial ATP-sensitive potassium channel.

Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Publishing Authors By Initials

Q Gao,HY Pan,Q Xia,I Bruce,

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Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 6

Page Numbers: 5591-4

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ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Information

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LANGUAGE: eng

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AFFILIATION: Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China (phone: 0086-571-87217146; fax: 0086-571-87217147; e-mail: gaoqin@zju.edu.cn).

Country: United States

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